The control of diseases such as malaria by altering insect metamorphosis. Introduction: Malaria is one of the most widespread vector-borne diseases common in tropical and subtropical areas of the world, including regions in Africa, Asia, and America. Malaria is caused by the protozoan parasites , belonging to the genus Plasmodium , residing in some female mosquitoes of the genus Anopheles .

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Answer 1

Question

Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

Chapter 21, Problem 1DQ

Summary Introduction

To review:

The control of diseases such as malaria by altering insect metamorphosis.

Introduction:

Malaria is one of the most widespread vector-borne diseases common in tropical and subtropical areas of the world, including regions in Africa, Asia, and America. Malaria is caused by the protozoan parasites, belonging to the genus Plasmodium, residing in some female mosquitoes of the genus Anopheles.

Expert Solution & Answer

Explanation of Solution

Hormonal control is essential for coordination and regulation of many aspects of the developmental process in many organisms. Insect molting and metamorphosis are controlled by two effector hormones: the steroid 20-hydroxyecdysone (20E) and the lipid juvenile hormone (JH). 20E has been characterized as the principal molting hormone in insects (Gilbert et al., 2002), which initiates and coordinates each molt (larva-to-larva, larva-to-pupa, pupa-to-adult) and regulates the gene expression changes that occur during metamorphosis. Molting and metamorphosis are initiated by a rise in the titer of the ecdysteroids. Upon initiation of the endocrine signaling, 20E binds to the ecdysone receptor (EcR), a member of the nuclear hormone receptor superfamily, which heterodimerizes with another nuclear receptor. The regulation of insect metamorphosis is controlled by the juvenile hormone (JH), ecdysone, and active hormone 20E. 20E and JH together cause molts forming next larval instar. The low concentration of JH, the 20E-induced molt produces pupa instead of larva. When 20E acts in the absence of JH, the imaginal discs differentiate and the molt gives rise to an adult (imago).

In Lepidoptera, there is one or more small peaks of ecdysteroids in the absence of JH following attainment of a critical weight that initiate metamorphic events such as wandering behavior. Then a high peak of ecdysteroids in the presence of JH initiates pupation. In numerous studies, precise fluctuations of ecdysteroid titers in last instar larval and in pupal stages of Ae. Aegypti have been determined. Many studies attempted to correlate ecdysteroid levels to gene expression profiles to measure ecdysteroid fluctuations in our system. Expression of ecdysone receptors, transcription factors and other ecdysone-regulated genes was compared with the timing of ecdysteroid peaks.

Conclusion

The future research focuses on the specific function(s) of ecdysone receptors and ecdysone regulated transcription factors during mosquito development to control malaria.

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Answer 2

Question

Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

Chapter 21, Problem 1DQ

Summary Introduction

To review:

The control of diseases such as malaria by altering insect metamorphosis.

Introduction:

Malaria is one of the most widespread vector-borne diseases common in tropical and subtropical areas of the world, including regions in Africa, Asia, and America. Malaria is caused by the protozoan parasites, belonging to the genus Plasmodium, residing in some female mosquitoes of the genus Anopheles.

Expert Solution & Answer

Explanation of Solution

Hormonal control is essential for coordination and regulation of many aspects of the developmental process in many organisms. Insect molting and metamorphosis are controlled by two effector hormones: the steroid 20-hydroxyecdysone (20E) and the lipid juvenile hormone (JH). 20E has been characterized as the principal molting hormone in insects (Gilbert et al., 2002), which initiates and coordinates each molt (larva-to-larva, larva-to-pupa, pupa-to-adult) and regulates the gene expression changes that occur during metamorphosis. Molting and metamorphosis are initiated by a rise in the titer of the ecdysteroids. Upon initiation of the endocrine signaling, 20E binds to the ecdysone receptor (EcR), a member of the nuclear hormone receptor superfamily, which heterodimerizes with another nuclear receptor. The regulation of insect metamorphosis is controlled by the juvenile hormone (JH), ecdysone, and active hormone 20E. 20E and JH together cause molts forming next larval instar. The low concentration of JH, the 20E-induced molt produces pupa instead of larva. When 20E acts in the absence of JH, the imaginal discs differentiate and the molt gives rise to an adult (imago).

In Lepidoptera, there is one or more small peaks of ecdysteroids in the absence of JH following attainment of a critical weight that initiate metamorphic events such as wandering behavior. Then a high peak of ecdysteroids in the presence of JH initiates pupation. In numerous studies, precise fluctuations of ecdysteroid titers in last instar larval and in pupal stages of Ae. Aegypti have been determined. Many studies attempted to correlate ecdysteroid levels to gene expression profiles to measure ecdysteroid fluctuations in our system. Expression of ecdysone receptors, transcription factors and other ecdysone-regulated genes was compared with the timing of ecdysteroid peaks.

Conclusion

The future research focuses on the specific function(s) of ecdysone receptors and ecdysone regulated transcription factors during mosquito development to control malaria.

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Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 3

Question

Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

Chapter 21, Problem 1DQ

Summary Introduction

To review:

The control of diseases such as malaria by altering insect metamorphosis.

Introduction:

Malaria is one of the most widespread vector-borne diseases common in tropical and subtropical areas of the world, including regions in Africa, Asia, and America. Malaria is caused by the protozoan parasites, belonging to the genus Plasmodium, residing in some female mosquitoes of the genus Anopheles.

Expert Solution & Answer

Explanation of Solution

Hormonal control is essential for coordination and regulation of many aspects of the developmental process in many organisms. Insect molting and metamorphosis are controlled by two effector hormones: the steroid 20-hydroxyecdysone (20E) and the lipid juvenile hormone (JH). 20E has been characterized as the principal molting hormone in insects (Gilbert et al., 2002), which initiates and coordinates each molt (larva-to-larva, larva-to-pupa, pupa-to-adult) and regulates the gene expression changes that occur during metamorphosis. Molting and metamorphosis are initiated by a rise in the titer of the ecdysteroids. Upon initiation of the endocrine signaling, 20E binds to the ecdysone receptor (EcR), a member of the nuclear hormone receptor superfamily, which heterodimerizes with another nuclear receptor. The regulation of insect metamorphosis is controlled by the juvenile hormone (JH), ecdysone, and active hormone 20E. 20E and JH together cause molts forming next larval instar. The low concentration of JH, the 20E-induced molt produces pupa instead of larva. When 20E acts in the absence of JH, the imaginal discs differentiate and the molt gives rise to an adult (imago).

In Lepidoptera, there is one or more small peaks of ecdysteroids in the absence of JH following attainment of a critical weight that initiate metamorphic events such as wandering behavior. Then a high peak of ecdysteroids in the presence of JH initiates pupation. In numerous studies, precise fluctuations of ecdysteroid titers in last instar larval and in pupal stages of Ae. Aegypti have been determined. Many studies attempted to correlate ecdysteroid levels to gene expression profiles to measure ecdysteroid fluctuations in our system. Expression of ecdysone receptors, transcription factors and other ecdysone-regulated genes was compared with the timing of ecdysteroid peaks.

Conclusion

The future research focuses on the specific function(s) of ecdysone receptors and ecdysone regulated transcription factors during mosquito development to control malaria.

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Answer 4

Question

Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

Chapter 21, Problem 1DQ

Summary Introduction

To review:

The control of diseases such as malaria by altering insect metamorphosis.

Introduction:

Malaria is one of the most widespread vector-borne diseases common in tropical and subtropical areas of the world, including regions in Africa, Asia, and America. Malaria is caused by the protozoan parasites, belonging to the genus Plasmodium, residing in some female mosquitoes of the genus Anopheles.

Expert Solution & Answer

Explanation of Solution

Hormonal control is essential for coordination and regulation of many aspects of the developmental process in many organisms. Insect molting and metamorphosis are controlled by two effector hormones: the steroid 20-hydroxyecdysone (20E) and the lipid juvenile hormone (JH). 20E has been characterized as the principal molting hormone in insects (Gilbert et al., 2002), which initiates and coordinates each molt (larva-to-larva, larva-to-pupa, pupa-to-adult) and regulates the gene expression changes that occur during metamorphosis. Molting and metamorphosis are initiated by a rise in the titer of the ecdysteroids. Upon initiation of the endocrine signaling, 20E binds to the ecdysone receptor (EcR), a member of the nuclear hormone receptor superfamily, which heterodimerizes with another nuclear receptor. The regulation of insect metamorphosis is controlled by the juvenile hormone (JH), ecdysone, and active hormone 20E. 20E and JH together cause molts forming next larval instar. The low concentration of JH, the 20E-induced molt produces pupa instead of larva. When 20E acts in the absence of JH, the imaginal discs differentiate and the molt gives rise to an adult (imago).

In Lepidoptera, there is one or more small peaks of ecdysteroids in the absence of JH following attainment of a critical weight that initiate metamorphic events such as wandering behavior. Then a high peak of ecdysteroids in the presence of JH initiates pupation. In numerous studies, precise fluctuations of ecdysteroid titers in last instar larval and in pupal stages of Ae. Aegypti have been determined. Many studies attempted to correlate ecdysteroid levels to gene expression profiles to measure ecdysteroid fluctuations in our system. Expression of ecdysone receptors, transcription factors and other ecdysone-regulated genes was compared with the timing of ecdysteroid peaks.

Conclusion

The future research focuses on the specific function(s) of ecdysone receptors and ecdysone regulated transcription factors during mosquito development to control malaria.

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Answer 5

Chapter 21, Problem 1DQ

Summary Introduction

To review:

The control of diseases such as malaria by altering insect metamorphosis.

Introduction:

Malaria is one of the most widespread vector-borne diseases common in tropical and subtropical areas of the world, including regions in Africa, Asia, and America. Malaria is caused by the protozoan parasites, belonging to the genus Plasmodium, residing in some female mosquitoes of the genus Anopheles.

Expert Solution & Answer

Explanation of Solution

Hormonal control is essential for coordination and regulation of many aspects of the developmental process in many organisms. Insect molting and metamorphosis are controlled by two effector hormones: the steroid 20-hydroxyecdysone (20E) and the lipid juvenile hormone (JH). 20E has been characterized as the principal molting hormone in insects (Gilbert et al., 2002), which initiates and coordinates each molt (larva-to-larva, larva-to-pupa, pupa-to-adult) and regulates the gene expression changes that occur during metamorphosis. Molting and metamorphosis are initiated by a rise in the titer of the ecdysteroids. Upon initiation of the endocrine signaling, 20E binds to the ecdysone receptor (EcR), a member of the nuclear hormone receptor superfamily, which heterodimerizes with another nuclear receptor. The regulation of insect metamorphosis is controlled by the juvenile hormone (JH), ecdysone, and active hormone 20E. 20E and JH together cause molts forming next larval instar. The low concentration of JH, the 20E-induced molt produces pupa instead of larva. When 20E acts in the absence of JH, the imaginal discs differentiate and the molt gives rise to an adult (imago).

In Lepidoptera, there is one or more small peaks of ecdysteroids in the absence of JH following attainment of a critical weight that initiate metamorphic events such as wandering behavior. Then a high peak of ecdysteroids in the presence of JH initiates pupation. In numerous studies, precise fluctuations of ecdysteroid titers in last instar larval and in pupal stages of Ae. Aegypti have been determined. Many studies attempted to correlate ecdysteroid levels to gene expression profiles to measure ecdysteroid fluctuations in our system. Expression of ecdysone receptors, transcription factors and other ecdysone-regulated genes was compared with the timing of ecdysteroid peaks.

Conclusion

The future research focuses on the specific function(s) of ecdysone receptors and ecdysone regulated transcription factors during mosquito development to control malaria.

Answer 6

Chapter 21, Problem 1DQ

Summary Introduction

To review:

The control of diseases such as malaria by altering insect metamorphosis.

Introduction:

Malaria is one of the most widespread vector-borne diseases common in tropical and subtropical areas of the world, including regions in Africa, Asia, and America. Malaria is caused by the protozoan parasites, belonging to the genus Plasmodium, residing in some female mosquitoes of the genus Anopheles.

Expert Solution & Answer

Explanation of Solution

Hormonal control is essential for coordination and regulation of many aspects of the developmental process in many organisms. Insect molting and metamorphosis are controlled by two effector hormones: the steroid 20-hydroxyecdysone (20E) and the lipid juvenile hormone (JH). 20E has been characterized as the principal molting hormone in insects (Gilbert et al., 2002), which initiates and coordinates each molt (larva-to-larva, larva-to-pupa, pupa-to-adult) and regulates the gene expression changes that occur during metamorphosis. Molting and metamorphosis are initiated by a rise in the titer of the ecdysteroids. Upon initiation of the endocrine signaling, 20E binds to the ecdysone receptor (EcR), a member of the nuclear hormone receptor superfamily, which heterodimerizes with another nuclear receptor. The regulation of insect metamorphosis is controlled by the juvenile hormone (JH), ecdysone, and active hormone 20E. 20E and JH together cause molts forming next larval instar. The low concentration of JH, the 20E-induced molt produces pupa instead of larva. When 20E acts in the absence of JH, the imaginal discs differentiate and the molt gives rise to an adult (imago).

In Lepidoptera, there is one or more small peaks of ecdysteroids in the absence of JH following attainment of a critical weight that initiate metamorphic events such as wandering behavior. Then a high peak of ecdysteroids in the presence of JH initiates pupation. In numerous studies, precise fluctuations of ecdysteroid titers in last instar larval and in pupal stages of Ae. Aegypti have been determined. Many studies attempted to correlate ecdysteroid levels to gene expression profiles to measure ecdysteroid fluctuations in our system. Expression of ecdysone receptors, transcription factors and other ecdysone-regulated genes was compared with the timing of ecdysteroid peaks.

Conclusion

The future research focuses on the specific function(s) of ecdysone receptors and ecdysone regulated transcription factors during mosquito development to control malaria.

Answer 7

Chapter 21, Problem 1DQ

Summary Introduction

To review:

The control of diseases such as malaria by altering insect metamorphosis.

Introduction:

Malaria is one of the most widespread vector-borne diseases common in tropical and subtropical areas of the world, including regions in Africa, Asia, and America. Malaria is caused by the protozoan parasites, belonging to the genus Plasmodium, residing in some female mosquitoes of the genus Anopheles.

Answer 8

Expert Solution & Answer

Explanation of Solution

Hormonal control is essential for coordination and regulation of many aspects of the developmental process in many organisms. Insect molting and metamorphosis are controlled by two effector hormones: the steroid 20-hydroxyecdysone (20E) and the lipid juvenile hormone (JH). 20E has been characterized as the principal molting hormone in insects (Gilbert et al., 2002), which initiates and coordinates each molt (larva-to-larva, larva-to-pupa, pupa-to-adult) and regulates the gene expression changes that occur during metamorphosis. Molting and metamorphosis are initiated by a rise in the titer of the ecdysteroids. Upon initiation of the endocrine signaling, 20E binds to the ecdysone receptor (EcR), a member of the nuclear hormone receptor superfamily, which heterodimerizes with another nuclear receptor. The regulation of insect metamorphosis is controlled by the juvenile hormone (JH), ecdysone, and active hormone 20E. 20E and JH together cause molts forming next larval instar. The low concentration of JH, the 20E-induced molt produces pupa instead of larva. When 20E acts in the absence of JH, the imaginal discs differentiate and the molt gives rise to an adult (imago).

In Lepidoptera, there is one or more small peaks of ecdysteroids in the absence of JH following attainment of a critical weight that initiate metamorphic events such as wandering behavior. Then a high peak of ecdysteroids in the presence of JH initiates pupation. In numerous studies, precise fluctuations of ecdysteroid titers in last instar larval and in pupal stages of Ae. Aegypti have been determined. Many studies attempted to correlate ecdysteroid levels to gene expression profiles to measure ecdysteroid fluctuations in our system. Expression of ecdysone receptors, transcription factors and other ecdysone-regulated genes was compared with the timing of ecdysteroid peaks.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Conclusion

The future research focuses on the specific function(s) of ecdysone receptors and ecdysone regulated transcription factors during mosquito development to control malaria.

Answer 12

Ch. 21 - Prob. 1DQ Ch. 21 - Prob. 2DQ

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