The enolate that is formed when the given ketone reacts with LDA has to be drawn. Concept Introduction: The structure of LDA : The name L D A stands for L i t h i u m d i i s o p r o p y l a m i d e . Since LDA is being a bulky base, it always prefers to attack only the less hindered site α- Carbon atom of ketone and forms the enolate which will be resonance stabilized. Enolate formation: When ketones are treated with a strong base, the α-position of the ketone will be deprotonated to give a resonance-stabilized intermediate called an enolate . Example:

Question

Want to see the full answer?

Answer 1

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21, Problem 113IP

Interpretation Introduction

Interpretation:

The enolate that is formed when the given ketone reacts with LDA has to be drawn.

Concept Introduction:

The structure of LDA :

The name LDA stands for Lithium diisopropyl amide.

Since LDA is being a bulky base, it always prefers to attack only the less hindered site α- Carbon atom of ketone and forms the enolate which will be resonance stabilized.

Enolate formation:

When ketones are treated with a strong base, the α-position of the ketone will be deprotonated to give a resonance-stabilized intermediate called an enolate.

Example:

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

show the retrosynthesis of this molecule step by step starting with 1,3-dimethoxy benzene H3CO OH OH OCH 3

Consider the reaction of a propanoate ester with hydroxide ion shown below. A series of four alcohol leaving groups were tested to determine which would be the best leaving group. Based on the pKa values of the alcohols, predict which alcohol would produce the fastest hydrolysis reaction. HO FOR A Alcohol I, pKa =16.0 B Alcohol II, pKa =10.0 C Alcohol III, pKa = 7.2 + ROH D Alcohol IV, pKa = 6.6

Curved arrows are used to illustrate the flow of electrons. Using the provided starting and product structures, draw the curved electron-pushing arrows for the following reaction or mechanistic step(s). Be sure to account for all bond-breaking and bond-making steps. :0: NaOH, H₂O 00:4 Na O heat NaO Select to Add Arrows Select to Add Arrows :0: Na a NaOH, H2O :0: NaOH, H2O heat heat Na ONH Select to Add Arrows

Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21, Problem 113IP

Interpretation Introduction

Interpretation:

The enolate that is formed when the given ketone reacts with LDA has to be drawn.

Concept Introduction:

The structure of LDA :

The name LDA stands for Lithium diisopropyl amide.

Since LDA is being a bulky base, it always prefers to attack only the less hindered site α- Carbon atom of ketone and forms the enolate which will be resonance stabilized.

Enolate formation:

When ketones are treated with a strong base, the α-position of the ketone will be deprotonated to give a resonance-stabilized intermediate called an enolate.

Example:

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21, Problem 113IP

Interpretation Introduction

Interpretation:

The enolate that is formed when the given ketone reacts with LDA has to be drawn.

Concept Introduction:

The structure of LDA :

The name LDA stands for Lithium diisopropyl amide.

Since LDA is being a bulky base, it always prefers to attack only the less hindered site α- Carbon atom of ketone and forms the enolate which will be resonance stabilized.

Enolate formation:

When ketones are treated with a strong base, the α-position of the ketone will be deprotonated to give a resonance-stabilized intermediate called an enolate.

Example:

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21, Problem 113IP

Interpretation Introduction