Essential Cell Biology (Fourth Edition)
Essential Cell Biology (Fourth Edition)
4th Edition
ISBN: 9780815345251
Author: Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D. Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 20, Problem 9Q

A.

Summary Introduction

To explain: Whether the statement “The Gap junctions connect the cytoskeleton of one cell to that of a neighboring cell or to the extracellular matrix is correct or incorrect.

B.

Summary Introduction

To explain: Whether the statement “A wilted plant leaf can be likened to a deflated bicycle tire is correct or incorrect.

C.

Summary Introduction

To explain: Whether the statement “Because of their rigid structure, Proteoglycans can withstand a large amount of compressive force is correct or incorrect.

D.

Summary Introduction

To explain: Whether the statement “The basal lamina is a specialized layer of extracellular matrix to which sheets of epithelial cells are attached is correct or incorrect.

E.

Summary Introduction

To explain: Whether the statement “Skin cells are continually shed and are renewed every few weeks; for a permanent tattoo, it is therefore necessary to deposit pigment below the epidermis is correct or incorrect.

F.

Summary Introduction

To explain: Whether the statement “Although stem cells are not differentiated, they are specialized and therefore give rise only to specific cell types is correct or incorrect.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
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Biomolecules - Protein - Amino acids; Author: Tutorials Point (India) Ltd.;https://www.youtube.com/watch?v=ySNVPDHJ0ek;License: Standard YouTube License, CC-BY