The product of the given reaction is has be given. Concept Introduction: Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Question

Want to see the full answer?

Answer 1

Question

Chapter 20, Problem 22P

(a)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(b)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(c)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

(d)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(e)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(f)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halide reacts with amine to form alkyl-substituted product. The reaction mechanism is nucleophilic aliphatic substitution. Amines are generally nucleophilic in nature. Therefore, the reaction easily occurs in mild conditions.

(g)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(h)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(i)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

1. Show the steps necessary to make 2-methyl-4-nonene using a Wittig reaction. Start with triphenylphosphine and an alkyl halide. After that you may use any other organic or inorganic reagents. 2. Write in the product of this reaction: CH3 CH₂ (C6H5)₂CuLi H₂O+

3. Name this compound properly, including stereochemistry. H₂C H3C CH3 OH 4. Show the step(s) necessary to transform the compound on the left into the acid on the right. Bri CH2 5. Write in the product of this LiAlH4 Br H₂C OH

What are the major products of the following reaction? Please provide a detailed explanation and a drawing to show how the reaction proceeds.

Answer 2

Question

Chapter 20, Problem 22P

(a)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(b)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(c)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

(d)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(e)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(f)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halide reacts with amine to form alkyl-substituted product. The reaction mechanism is nucleophilic aliphatic substitution. Amines are generally nucleophilic in nature. Therefore, the reaction easily occurs in mild conditions.

(g)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(h)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(i)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 20, Problem 22P

(a)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(b)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(c)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

(d)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(e)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(f)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halide reacts with amine to form alkyl-substituted product. The reaction mechanism is nucleophilic aliphatic substitution. Amines are generally nucleophilic in nature. Therefore, the reaction easily occurs in mild conditions.

(g)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(h)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(i)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 20, Problem 22P

(a)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(b)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(c)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

(d)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(e)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(f)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halide reacts with amine to form alkyl-substituted product. The reaction mechanism is nucleophilic aliphatic substitution. Amines are generally nucleophilic in nature. Therefore, the reaction easily occurs in mild conditions.

(g)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(h)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(i)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 20, Problem 22P

(a)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(b)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(c)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

(d)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(e)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(f)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halide reacts with amine to form alkyl-substituted product. The reaction mechanism is nucleophilic aliphatic substitution. Amines are generally nucleophilic in nature. Therefore, the reaction easily occurs in mild conditions.

(g)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

(h)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

(i)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 6

Chapter 20, Problem 22P

(a)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 7

Chapter 20, Problem 22P

(a)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 8

(b)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

Answer 9

(b)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

Answer 10

(c)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

Answer 11

(c)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

Answer 12

(d)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 13

(d)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 14

(e)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

Answer 15

(e)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

Answer 16

(f)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halide reacts with amine to form alkyl-substituted product. The reaction mechanism is nucleophilic aliphatic substitution. Amines are generally nucleophilic in nature. Therefore, the reaction easily occurs in mild conditions.

Answer 17

(f)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halide reacts with amine to form alkyl-substituted product. The reaction mechanism is nucleophilic aliphatic substitution. Amines are generally nucleophilic in nature. Therefore, the reaction easily occurs in mild conditions.

Answer 18

(g)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 19

(g)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 20

(h)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

Answer 21

(h)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions. Nucleophile adds to the ring carbon attached to the leaving group. Then, the leaving group is eliminated. Substitution takes place at C-2 or C-4 because it leads to the most stable intermediate.

Answer 22

(i)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 23

(i)

Interpretation Introduction

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Aromatic five-membered heterocyclic compounds undergo electrophilic aromatic substitution reactions preferentially at 2-position. The intermediate obtained by adding a substituent to this position is more stable than the intermediate obtained by adding a substituent to C-3 position.

Answer 24

Expert Solution & Answer

Answer 25

Expert Solution & Answer

Answer 26

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 27

Ch. 20.1 - Name the following:Ch. 20.2 - Prob. 2P Ch. 20.2 - Prob. 3P Ch. 20.3 - Draw the product of each of the following...Ch. 20.5 - Prob. 6P Ch. 20.5 - When pyrrole is added to a dilute solution of...Ch. 20.5 - Explain why cyclopentadiene (pKa = 15) is more...Ch. 20.6 - Prob. 10P Ch. 20.6 - How to the mechanisms of the following reactions...Ch. 20.6 - Prob. 12P

Solution Summary: The author explains that Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions.

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

Want to see the full answer?

Chapter 20 Solutions

Solution Summary: The author explains that Pyridine is more reactive than benzene towards nucleophilic aromatic substitution reactions.

Interpretation: The product of the given reaction is has be given. Concept Introduction: Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.

Want to see the full answer?

Chapter 20 Solutions

Interpretation:

The product of the given reaction is has be given.

Concept Introduction:

Alkyl halides undergo nucleophilic substitution reaction with cyanide ions to give nitriles. Nitriles are reduced to amines in the presence of H2 and raney Ni.