ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 20, Problem 1CAL
If a patient has cirrhosis of the liver and is unable to produce sufficient albumin and other plasma proteins, then what variable is changed in capillary exchange, and what is the effect?
- a. There is no change in the capillary exchange process.
- b. Hydrostatic pressure in the blood decreases, and fluid remains in the blood.
- c. Colloid osmotic pressure in the capillary increases, and blood volume increases in the blood vessels.
- d. Colloid osmotic pressure in the capillary decreases, and fluid remains in the interstitial fluid, potentially causing edema.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 20 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 20.1 - What are three differences in anatomic structure...Ch. 20.1 - Prob. 2WDYLCh. 20.1 - What type of capillary is the most permeable, and...Ch. 20.1 - Prob. 4WDYLCh. 20.1 - Prob. 5WDYLCh. 20.2 - In which type of vessel is blood flow the slowest?...Ch. 20.3 - What substances are transported by diffusion...Ch. 20.3 - Prob. 8WDYLCh. 20.3 - How does the hydrostatic pressure change from the...Ch. 20.3 - Which two pressures have the largest values?...
Ch. 20.3 - If these lymph vessels were nonfunctional, what...Ch. 20.4 - In what ways is angiogenesis stimulated in...Ch. 20.4 - Prob. 13WDYLCh. 20.4 - What relationship exists between metabolic...Ch. 20.4 - Prob. 15WDYLCh. 20.5 - Prob. 16WDYLCh. 20.5 - Prob. 17WDYLCh. 20.5 - How is the small pressure gradient in veins...Ch. 20.5 - How is the pressure gradient to move blood through...Ch. 20.5 - How is resistance defined?Ch. 20.5 - What are the three factors that alter resistance?...Ch. 20.5 - Prob. 22WDYLCh. 20.6 - Prob. 23WDYLCh. 20.6 - What is the initial change to blood pressure when...Ch. 20.6 - Prob. 25WDYLCh. 20.6 - Prob. 26WDYLCh. 20.7 - Which organs have an increased proportion of...Ch. 20.8 - Prob. 28WDYLCh. 20.8 - Prob. 29WDYLCh. 20.9 - Prob. 30WDYLCh. 20.9 - Prob. 31WDYLCh. 20.10 - Prob. 32WDYLCh. 20.10 - Prob. 33WDYLCh. 20.10 - Prob. 34WDYLCh. 20.10 - What are the systemic arteries that supply...Ch. 20.10 - Prob. 36WDYLCh. 20.10 - Prob. 37WDYLCh. 20.10 - Prob. 38WDYLCh. 20.11 - Prob. 39WDYLCh. 20.11 - Prob. 40WDYLCh. 20.11 - Prob. 41WDYLCh. 20.11 - Prob. 42WDYLCh. 20.12 - List the five structures of fetal circulation, and...Ch. 20.12 - Prob. 44WDYLCh. 20 - _____ 1. Which of the following is not a...Ch. 20 - _____ 2. Which statement is accurate about veins?...Ch. 20 - _____ 3. Vasa vasorum are found in the tunica...Ch. 20 - _____ 4. Which of the following decreases...Ch. 20 - _____ 5. The __________ is a type of vessel with...Ch. 20 - _____ 6. An increase in _____ will result in an...Ch. 20 - Prob. 7DYKBCh. 20 - _____ 8. Velocity of blood flow is the slowest in...Ch. 20 - _____ 9. Blood pressure is regulated by the a....Ch. 20 - _____ 10. Name the correct pathway that blood...Ch. 20 - Prob. 11DYKBCh. 20 - Prob. 12DYKBCh. 20 - Explain the difference between hydrostatic and...Ch. 20 - Write the formula for determining net filtration...Ch. 20 - Prob. 15DYKBCh. 20 - Prob. 16DYKBCh. 20 - Briefly explain how changes in cardiac output,...Ch. 20 - Compare how the cardiac center and vasomotor...Ch. 20 - Prob. 19DYKBCh. 20 - What postnatal changes occur in the heart and...Ch. 20 - If a patient has cirrhosis of the liver and is...Ch. 20 - Prob. 2CALCh. 20 - Prob. 3CALCh. 20 - Prob. 4CALCh. 20 - Prob. 5CALCh. 20 - Prob. 1CSLCh. 20 - Arteries tend to have a lot of vascular...Ch. 20 - Explain why an overweight individual with high...
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