ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Textbook Question
Chapter 20.10, Problem 35WDYL
What are the systemic arteries that supply oxygenated blood to the lungs? What specific structures of the lung receive the blood?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 20 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 20.1 - What are three differences in anatomic structure...Ch. 20.1 - Prob. 2WDYLCh. 20.1 - What type of capillary is the most permeable, and...Ch. 20.1 - Prob. 4WDYLCh. 20.1 - Prob. 5WDYLCh. 20.2 - In which type of vessel is blood flow the slowest?...Ch. 20.3 - What substances are transported by diffusion...Ch. 20.3 - Prob. 8WDYLCh. 20.3 - How does the hydrostatic pressure change from the...Ch. 20.3 - Which two pressures have the largest values?...
Ch. 20.3 - If these lymph vessels were nonfunctional, what...Ch. 20.4 - In what ways is angiogenesis stimulated in...Ch. 20.4 - Prob. 13WDYLCh. 20.4 - What relationship exists between metabolic...Ch. 20.4 - Prob. 15WDYLCh. 20.5 - Prob. 16WDYLCh. 20.5 - Prob. 17WDYLCh. 20.5 - How is the small pressure gradient in veins...Ch. 20.5 - How is the pressure gradient to move blood through...Ch. 20.5 - How is resistance defined?Ch. 20.5 - What are the three factors that alter resistance?...Ch. 20.5 - Prob. 22WDYLCh. 20.6 - Prob. 23WDYLCh. 20.6 - What is the initial change to blood pressure when...Ch. 20.6 - Prob. 25WDYLCh. 20.6 - Prob. 26WDYLCh. 20.7 - Which organs have an increased proportion of...Ch. 20.8 - Prob. 28WDYLCh. 20.8 - Prob. 29WDYLCh. 20.9 - Prob. 30WDYLCh. 20.9 - Prob. 31WDYLCh. 20.10 - Prob. 32WDYLCh. 20.10 - Prob. 33WDYLCh. 20.10 - Prob. 34WDYLCh. 20.10 - What are the systemic arteries that supply...Ch. 20.10 - Prob. 36WDYLCh. 20.10 - Prob. 37WDYLCh. 20.10 - Prob. 38WDYLCh. 20.11 - Prob. 39WDYLCh. 20.11 - Prob. 40WDYLCh. 20.11 - Prob. 41WDYLCh. 20.11 - Prob. 42WDYLCh. 20.12 - List the five structures of fetal circulation, and...Ch. 20.12 - Prob. 44WDYLCh. 20 - _____ 1. Which of the following is not a...Ch. 20 - _____ 2. Which statement is accurate about veins?...Ch. 20 - _____ 3. Vasa vasorum are found in the tunica...Ch. 20 - _____ 4. Which of the following decreases...Ch. 20 - _____ 5. The __________ is a type of vessel with...Ch. 20 - _____ 6. An increase in _____ will result in an...Ch. 20 - Prob. 7DYKBCh. 20 - _____ 8. Velocity of blood flow is the slowest in...Ch. 20 - _____ 9. Blood pressure is regulated by the a....Ch. 20 - _____ 10. Name the correct pathway that blood...Ch. 20 - Prob. 11DYKBCh. 20 - Prob. 12DYKBCh. 20 - Explain the difference between hydrostatic and...Ch. 20 - Write the formula for determining net filtration...Ch. 20 - Prob. 15DYKBCh. 20 - Prob. 16DYKBCh. 20 - Briefly explain how changes in cardiac output,...Ch. 20 - Compare how the cardiac center and vasomotor...Ch. 20 - Prob. 19DYKBCh. 20 - What postnatal changes occur in the heart and...Ch. 20 - If a patient has cirrhosis of the liver and is...Ch. 20 - Prob. 2CALCh. 20 - Prob. 3CALCh. 20 - Prob. 4CALCh. 20 - Prob. 5CALCh. 20 - Prob. 1CSLCh. 20 - Arteries tend to have a lot of vascular...Ch. 20 - Explain why an overweight individual with high...
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