Anatomy & Physiology
5th Edition
ISBN: 9780321861580
Author: Marieb, Elaine N.
Publisher: Pearson College Div
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Chapter 20, Problem 13CYU
Why is the secondary response to an antigen so much faster than the primary response?
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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the
encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid
is located on the outside of the soluble protein but not near an active site.
O-H¨
A. What type of mutation occurred?
O-H
B. What 2 types of chemical bonds are found in the R-groups
of each amino acid? The R groups are shaded.
CH2
CH2
CH2
H2N-C-COOH
H2N-C-COOH
1
H
Glutamic acid
H
Aspartic acid
C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules?
D. Consider the chemical properties of the two amino acids and the location of the amino acid in the
protein. Explain what effect this mutation will have on this protein's function and why.
engineered constructs that consist of hollow fibers are acting as synthetic capillaries, around which cells have been loaded. The cellular space around a single fiber can be modeled as if it were a Krogh tissue cylinder. Each fiber has an outside “capillary” radius of 100 µm and the “tissue” radius can be taken as 200 µm. The following values apply to the device:R0 = 20 µM/secaO2 = 1.35 µM/mmHgDO2,T = 1.67 x 10-5 cm2/secPO2,m = 4 x 10-3 cm/secInstead of blood inside the fibers, the oxygen transport and tissue consumption are being investigated by usingan aqueous solution saturated with pure oxygen. As a result, there is no mass transfer resistance in the synthetic“capillary”, only that due to the membrane itself. Rather than accounting for pO2 variations along the length ofthe fiber, use an average value in the “capillary” of 130 mmHg.Is the tissue fully oxygenated?
Chapter 20 Solutions
Anatomy & Physiology
Ch. 20 - What distinguishes the innate defense system from...Ch. 20 - What is the first line of defense against disease?Ch. 20 - What is opsonization and how does it help...Ch. 20 - Under what circumstances might NK cells kill our...Ch. 20 - What are the cardinal signs of inflammation and...Ch. 20 - Name three key characteristics of adaptive...Ch. 20 - What is the difference between a complete antigen...Ch. 20 - What marks a cell as self as opposed to nonselfCh. 20 - What event (or observation) signals that a B or T...Ch. 20 - Which of the following T cells would survive...
Ch. 20 - Prob. 11CYUCh. 20 - In clonal selection, who does the selecting? What...Ch. 20 - Why is the secondary response to an antigen so...Ch. 20 - Prob. 14CYUCh. 20 - Which class of antibody is most abundant in blood?...Ch. 20 - List four ways in which antibodies can bring about...Ch. 20 - Class II MHC proteins display what kind of...Ch. 20 - Prob. 18CYUCh. 20 - Which type of T cell is the most important in both...Ch. 20 - Describe the killing mechanism of cytotoxic T...Ch. 20 - Prob. 21CYUCh. 20 - Prob. 22CYUCh. 20 - Prob. 23CYUCh. 20 - All of the following are considered innate body...Ch. 20 - The process by which neutrophils squeeze through...Ch. 20 - Antibodies released by plasma cells are involved...Ch. 20 - Which of the following antibodies can fix...Ch. 20 - Which antibody class is abundant in body...Ch. 20 - Small molecules that must combine with large...Ch. 20 - Lymphocytes that develop immunocompetence in the...Ch. 20 - Cells that can directly attack target cells...Ch. 20 - Prob. 9RQCh. 20 - The cell type most often invaded by HIV is a(n)...Ch. 20 - Complement fixation promotes all of the following...Ch. 20 - Using the letters from column B, match the cell...Ch. 20 - Besides acting as mechanical barriers, the skin...Ch. 20 - Explain why attempts at phagocytosis are not...Ch. 20 - What is complement? How does it cause bacterial...Ch. 20 - Interferons are referred to as antiviral proteins....Ch. 20 - Differentiate between humoral and cellular...Ch. 20 - Although the adaptive immune system has two arms,...Ch. 20 - Define immunocompetence and self-tolerance. How is...Ch. 20 - Differentiate between a primary and a secondary...Ch. 20 - Prob. 21RQCh. 20 - What is the role of the variable regions of an...Ch. 20 - Name the five antibody classes and describe where...Ch. 20 - How do antibodies help defend the body?Ch. 20 - Do vaccines produce active or passive humoral...Ch. 20 - Prob. 26RQCh. 20 - Describe the specific roles of helper, regulatory,...Ch. 20 - Prob. 28RQCh. 20 - Prob. 29RQCh. 20 - What events can result in autoimmune disease?Ch. 20 - Prob. 1CCSCh. 20 - Prob. 2CCSCh. 20 - Prob. 3CCSCh. 20 - Prob. 4CCSCh. 20 - Prob. 5CCS
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