Human Physiology
Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Chapter 20, Problem 13aCP

List the fetal and maternal components of the placenta and describe the circulation in these two components. Explain how fetal and maternal gas exchange occurs.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0  Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present.  Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Chapter 20 Solutions

Human Physiology

Ch. 20 - Prob. 5bCPCh. 20 - Prob. 6aCPCh. 20 - Prob. 6bCPCh. 20 - Describe the roles of FSH and testosterone in...Ch. 20 - Prob. 8aCPCh. 20 - Prob. 8bCPCh. 20 - Prob. 9aCPCh. 20 - Prob. 9bCPCh. 20 - Describe the changes that occur in the ovary and...Ch. 20 - Describe the formation, function, and fate of the...Ch. 20 - Prob. 11aCPCh. 20 - Explain the significance of negative feedback...Ch. 20 - Prob. 12aCPCh. 20 - Prob. 12bCPCh. 20 - List the fetal and maternal components of the...Ch. 20 - Prob. 13bCPCh. 20 - Prob. 14CPCh. 20 - Prob. 15CPCh. 20 - Prob. 1RACh. 20 - Prob. 2RACh. 20 - Prob. 3RACh. 20 - Prob. 4RACh. 20 - Prob. 5RACh. 20 - Prob. 6RACh. 20 - Prob. 7RACh. 20 - Prob. 8RACh. 20 - Which of these statements is true? Ch. 20 - Prob. 10RACh. 20 - Prob. 11RACh. 20 - Prob. 12RACh. 20 - Prob. 13RACh. 20 - Prob. 14RACh. 20 - Prob. 15RACh. 20 - The contents of the birth control pill Ch. 20 - Which of the following statements regarding...Ch. 20 - Prob. 18RACh. 20 - Prob. 19RACh. 20 - Prob. 20RACh. 20 - Prob. 21RACh. 20 - Prob. 22RACh. 20 - Prob. 23RACh. 20 - Prob. 24RACh. 20 - Prob. 25RACh. 20 - Prob. 26RACh. 20 - Prob. 27RACh. 20 - Describe the steps of oogenesis when fertilization...Ch. 20 - Prob. 29RACh. 20 - Prob. 30RACh. 20 - Prob. 31RACh. 20 - Prob. 32RACh. 20 - Prob. 33RACh. 20 - Prob. 34RACh. 20 - Prob. 35RACh. 20 - Prob. 36RACh. 20 - Prob. 37RACh. 20 - Prob. 38RACh. 20 - Prob. 39RACh. 20 - Prob. 40RACh. 20 - Prob. 41RACh. 20 - Prob. 42RACh. 20 - Prob. 43RACh. 20 - Prob. 44RA
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Embryology | Fertilization, Cleavage, Blastulation; Author: Ninja Nerd;https://www.youtube.com/watch?v=8-KF0rnhKTU;License: Standard YouTube License, CC-BY