Essentials of Human Anatomy & Physiology (12th Edition)
12th Edition
ISBN: 9780134395326
Author: Elaine N. Marieb, Suzanne M. Keller
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 2, Problem 45CT
Summary Introduction
To analyze:
The change in one amino acid could affect hemoglobin function.
Introduction:
The hemoglobin is a multi-subunit protein that carries the oxygen throughout the body via red blood cells (RBCs). Sickle cell anemia (SCA) is a condition in which the shape of the hemoglobin is changed and so, its function is altered. The genetic error that causes SCA begins at the DNA (deoxyribonucleic acid) level. Thus, the synthesized hemoglobin has one amino acid difference as compared to the normal hemoglobin.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Anemia is characterized by low hemoglobin levels or a reduced number of red blood cells (both of which transport oxygen to cells). A common symptom of anemia is tiredness. Please do not copy answers from another website/source.
a) Briefly explain what the consequences are of anemia on cellular energy production.
b) Suggest at least one other cellular effect of anemia and a brief explanation of this effect.
Sickle cells are named because of their characteristic shape. What problems can this shape cause?
Explain how the absence of a nucleus affects a red blood cell’s life span.
What is the gene code for hemoglobin?
Chapter 2 Solutions
Essentials of Human Anatomy & Physiology (12th Edition)
Ch. 2 - Prob. 1MCCh. 2 - 2. Pick out the correct match(es) of element and...Ch. 2 - Important functions of water include which of the...Ch. 2 - 4. Alkaline substances include which of the...Ch. 2 - Glucose is to starch as a. a steroid is to a...Ch. 2 - 6. What lipid type is stored in fat deposits...Ch. 2 - Absence of which of the following...Ch. 2 - ATP is not associated with a. a basic nucleotide...Ch. 2 - The element essential for normal thyroid function...Ch. 2 - 10. Factors that increase the speed of chemical...
Ch. 2 - Why is a study of basic chemistry essential to...Ch. 2 - Matter occupies space and has mass. Explain how...Ch. 2 - Prob. 13SAECh. 2 - Prob. 14SAECh. 2 - Prob. 15SAECh. 2 - Prob. 16SAECh. 2 - All atoms are neutral. Explain the basis of this...Ch. 2 - Fill in the following table to fully describe an...Ch. 2 - Define radioactivity. If an element has three...Ch. 2 - Prob. 20SAECh. 2 - Prob. 21SAECh. 2 - Prob. 22SAECh. 2 - The two oxygen atoms forming molecules of oxygen...Ch. 2 - Prob. 24SAECh. 2 - 25. Identify each of the following reactions as a...Ch. 2 - Prob. 26SAECh. 2 - Prob. 27SAECh. 2 - 28. Define pH. The pH range of blood is from 7.35...Ch. 2 - Prob. 29SAECh. 2 - Prob. 30SAECh. 2 - Prob. 31SAECh. 2 - Prob. 32SAECh. 2 - 33. Name the two protein classes based on...Ch. 2 - Prob. 34SAECh. 2 - Prob. 35SAECh. 2 - 36. What is the structural unit of nucleic acids?...Ch. 2 - Prob. 37SAECh. 2 - 38. Explain why you can “stack” water slightly...Ch. 2 - Water is a precious natural resource in...Ch. 2 - Explain the unique chemical makeup and...Ch. 2 - 41. Several antibiotics act by binding to certain...Ch. 2 - 42. Mrs. Roberts, who is in a diabetic coma, has...Ch. 2 - Sarah is quite proud of her slender, model-like...Ch. 2 - Prob. 44CTCh. 2 - Prob. 45CT
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Name the base change and the amino acid change, responsible for sickle cellanaemia.arrow_forwardIs there non-functional leukopoiesis in Leukemoid Reaction?arrow_forwardsickle hemoglobin when deoxygenated will create a long line of protein cells? is this true? Please explain your answer. thanksarrow_forward
- In humans, iron is a trace element required for the proper functioning of hemoglobin, the molecule that carries oxygen in red blood cells. What might be the effects of an iron deficiency?arrow_forwardAnemia is characterized by low hemoglobin levels or a reduced number of red blood cells (both of which transport oxygen to cells). A common symptom of anemia is tiredness. a) Explain what the consequences are of anemia on cellular energy production. b) Suggest at least one other cellular effects of anemia and an explanation of this effect.arrow_forwardwhat is the role that B^s-phe85 and Bs-Leu88 play in sickle cell anemia. please give a shirt and direct answerarrow_forward
- sickle cell disease and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin . propose a proper therapeutic strategy to ameliorate or cure this disease.arrow_forwardMatch the descriptor in the left hand column to the type of molecule it describes listed in the right hand column.. Question 4 options: hemoglobin molecule with heme groups containing iron atoms in the reduced state to which carbon monoxide molecules are attached hemoglobin molecule with heme groups containing iron atoms in the reduced state to which oxygen molecules are attached hemoglobin molecule with heme groups containing iron atoms in the oxidized state to which no oxygen molecules can attach hemoglobin molecule with heme groups containing iron atoms in the reduced state to which no oxygen molecules are attached hemoglobin molecule with heme groups containing iron atoms in the reduced state and carbon dioxide molecules attached to amino acid residues of the globin chains 1. carbaminohemoglobin 2. carboxyhemoglobin 3. deoxyhemoglobin 4. methemoglobin 5. oxyhemoblobinarrow_forwardWhich of the following models best represents this statement: "Sickle Cell Anemia is caused by a genetic mutation that affects the structure and function of hemoglobin in the red blood cell."arrow_forward
- Can all abnormal hemoglobin be diagnosed by electrophoresis ?Explain why or why not .arrow_forwarda) Hemoglobin accounts for 95% of the protein in red blood cells. If you Google the number of hemoglobin molecules in a RBC, most sources state 250-270 million hemoglobin molecules. If hemoglobin has a molecular weight of 67,000 Da, what is the concentration of hemoglobin in RBCs? Show your work and show your units. Use dimensional analysis to have your final answer in moles per liter. B) The hemoglobin molecule is nearly spherical with a diameter of 55 Angstroms. You can look at the 3D structure of human hemoglobin on the RCSB PDB website. Calculate the volume of a hemoglobin molecule, and can the number of hemoglobin molecules quoted in Question a actually fit into one red blood cell?arrow_forwardHemoglobin is an enzyme containing amino acids linked by peptide bonds. Select one: True Falsearrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Human Biology (MindTap Course List)BiologyISBN:9781305112100Author:Cecie Starr, Beverly McMillanPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Human Biology (MindTap Course List)
Biology
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cengage Learning