Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 2, Problem 2P
During the millennia in which selective breeding was practiced, why did breeders fail to uncover the principle that traits are governed by discrete units of inheritance (that is, by genes)?
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The following table is from Kumar et. al. Highly Selective Dopamine D3 Receptor (DR) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J. Med Chem 2016.
The following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the
pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin.
You are a chef in a fancy new science-themed restaurant. You have a recipe that calls for 1 teaspoon of resinferatoxin, but you feel uncomfortable serving foods with "toxins" in them. How much capsaicin could you substitute instead?
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Chapter 2 Solutions
Genetics: From Genes to Genomes
Ch. 2 - For each of the terms in the left column, choose...Ch. 2 - During the millennia in which selective breeding...Ch. 2 - Describe the characteristics of the garden pea...Ch. 2 - An albino corn snake is crossed with a...Ch. 2 - Two short-haired cats mate and produce six...Ch. 2 - Piebald spotting is a condition found in humans in...Ch. 2 - As a Drosophila research geneticist, you keep...Ch. 2 - A mutant cucumber plant has flowers that fail to...Ch. 2 - In a particular population of mice, certain...Ch. 2 - In humans, a dimple in the chin is a dominant...
Ch. 2 - Some inbred strains of the weedy plant Arabidopsis...Ch. 2 - Among Native Americans, two types of earwax...Ch. 2 - Imagine you have just purchased a black stallion...Ch. 2 - If you roll a die singular of dice, what is the...Ch. 2 - In a standard deck of playing cards, four suits...Ch. 2 - How many genetically different eggs could be...Ch. 2 - What is the probability of producing a child that...Ch. 2 - A mouse sperm of genotype a B C D E fertilizes an...Ch. 2 - Your friend is pregnant with triplets. She thinks...Ch. 2 - Galactosemia is a recessive human disease that is...Ch. 2 - Albinism is a condition in which pigmentation is...Ch. 2 - A cross between two pea plants, both of which grew...Ch. 2 - A third-grader decided to breed guinea pigs for...Ch. 2 - The self-fertilization of an pea plant produced...Ch. 2 - The achoo syndrome sneezing in response to bright...Ch. 2 - A pea plant from a pure-breeding strain that is...Ch. 2 - The following table shows the results of different...Ch. 2 - A pea plant heterozygous for plant height, pod...Ch. 2 - In the fruit fly Drosophila melanogaster, the...Ch. 2 - Based on the information you discovered in the...Ch. 2 - Considering the yellow and green pea color...Ch. 2 - What would have been the outcome the genotypic and...Ch. 2 - Recall that Mendel obtained pure-breeding with...Ch. 2 - The gene that likely controlled flower color...Ch. 2 - For each of the following human pedigrees,...Ch. 2 - Consider the pedigree that follows for cutis laxa,...Ch. 2 - A young couple went to see a genetic counselor...Ch. 2 - Huntington disease is a rare fatal, degenerative...Ch. 2 - Is the disease shown in the following pedigree...Ch. 2 - Figure 2.22 shows the inheritance of Huntington...Ch. 2 - Consider the cystic fibrosis pedigree in Figure...Ch. 2 - Prob. 42PCh. 2 - People with nail-patella syndrome have poorly...Ch. 2 - Midphalangeal hair hair on top of the middle...Ch. 2 - A man with Huntington disease he is heterozygous...Ch. 2 - Explain why disease alleles for cystic fibrosis CF...Ch. 2 - The following pedigree shows the inheritance of...
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- 1. Match each vocabulary term to its best descriptor A. affinity B. efficacy C. inert D. mimic E. how drugs move through body F. how drugs bind Kd Bmax Agonist Antagonist Pharmacokinetics Pharmacodynamicsarrow_forward50 mg dose of a drug is given orally to a patient. The bioavailability of the drug is 0.2. What is the volume of distribution of the drug if the plasma concentration is 1 mg/L? Be sure to provide units.arrow_forwardDetermine Kd and Bmax from the following Scatchard plot. Make sure to include units.arrow_forward
- Choose a catecholamine neurotransmitter and describe/draw the components of the synapse important for its signaling including synthesis, packaging into vesicles, receptors, transporters/degradative enzymes. Describe 2 drugs that can act on this system.arrow_forwardThe following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forward
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