Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 2, Problem 22PDQ
Summary Introduction
To review:
The folded-fiber model of the mitotic chromosome.
Introduction:
Chromosomes are the complex structural organizations of the DNA (deoxyribonucleic acid) and protein in the cell. To explain the formation of this complex structure, different models were given but the best model was the “folded-fiber” model by DuPraw in 1965. This structure explains the organization of the DNA and histone proteins inside the cell nucleus. He proposed this model on the basis of his studies of the human chromosome by electron microscopy.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 2 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 2 - CASE STUDY | Timing is everything A man in his...Ch. 2 - CASE STUDY | Timing is everything A man in his...Ch. 2 - CASE STUDY | Timing is everything A man in his...Ch. 2 -
HOW DO WE KNOW?
1. In this chapter, we focused...Ch. 2 -
2. Review the Chapter Concepts list on page 12....Ch. 2 - What role do the following cellular components...Ch. 2 -
4. Discuss the concepts of homologous...Ch. 2 - If two chromosomes of a species are the same...Ch. 2 - Describe the events that characterize each stage...Ch. 2 - How are chromosomes named on the basis of their...
Ch. 2 - Prob. 8PDQCh. 2 -
9. Describe the phases of the cell cycle and the...Ch. 2 - Define and discuss these terms: (a) synapsis, (b)...Ch. 2 - Prob. 11PDQCh. 2 - Prob. 12PDQCh. 2 - Contrast spermatogenesis and oogenesis. What is...Ch. 2 -
14. Explain why meiosis leads to significant...Ch. 2 -
15. A diploid cell contains three pairs of...Ch. 2 - Prob. 16PDQCh. 2 -
17. During oogenesis in an animal species with a...Ch. 2 - Prob. 18PDQCh. 2 -
19. During the first meiotic prophase, (a) when...Ch. 2 -
20. Describe the role of meiosis in the life...Ch. 2 - Prob. 21PDQCh. 2 - Prob. 22PDQCh. 2 - Prob. 23PDQCh. 2 -
24. If one follows 50 primary oocytes in an...Ch. 2 -
25. The nuclear DNA content of a single sperm...Ch. 2 - For Problems 26–31, consider a diploid cell that...Ch. 2 - For Problems 26–31, consider a diploid cell that...Ch. 2 - For Problems 26–31, consider a diploid cell that...Ch. 2 -
For Problems 26–31, consider a diploid cell that...Ch. 2 - For Problems 26–31, consider a diploid cell that...Ch. 2 - For Problems 26–31, consider a diploid cell that...
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