Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 19.4, Problem 3R
Summary Introduction
To review:
Evolutionary development in the human populations immune to Plasmodium vivax due to the presence of a mutated enhancer for the glycoprotein present on their red blood corpuscles (RBCs).
Introduction:
A protist named P. vivax is mainly responsible for causing malaria. It gets attached to the RBCs after entering the blood. It has been found that some human populations in Africa are immune to P. vivax due to the absence of this particular glycoprotein on their RBCs. The transcription of this glycoprotein is influenced by the enhancers in a variety of tissues. In individuals immune to this form of malaria, the enhancer that is normally expressed in RBC precursors is mutated.
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A 25-year-old woman presents to the emergency department with a 2-day history of fever, chills, severe headache, and confusion. She recently returned from a trip to sub-Saharan Africa, where she did not take malaria prophylaxis. On examination, she is febrile (39.8°C/103.6°F) and hypotensive. Laboratory studies reveal hemoglobin of 8.0 g/dL, platelet count of 50,000/μL, and evidence of hemoglobinuria. A peripheral blood smear shows ring forms and banana-shaped gametocytes. Which of the following Plasmodium species is most likely responsible for her severe symptoms?
A.
Plasmodium vivax
B.
Plasmodium ovale
C.
Plasmodium malariae
D.
Plasmodium falciparum
Standard Concentration (caffeine) mg/L
Absorbance Reading
10
0.322
20
0.697
40
1.535
60
2.520
80
3.100
Please draw in the missing answer, thank you
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Life: The Science of Biology
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