Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 19.1, Problem 1ELO
1. Describe how cellular characteristics are used to categorize gram-positive bacilli into major groups.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 19 Solutions
Foundations in Microbiology
Ch. 19.1 - 1. Describe how cellular characteristics are used...Ch. 19.1 - 1. Explain why Bacillus, Clostridium, and...Ch. 19.2 - 2. Recall the general characteristics of the genus...Ch. 19.2 - 3. Distinguish between cutaneous and pulmonary...Ch. 19.2 - 4. State the general characteristics of the genus...Ch. 19.2 - 5. Recall the organisms responsible for...Ch. 19.2 - Prob. 6ELOCh. 19.2 - Prob. 7ELOCh. 19.2 - Prob. 8ELOCh. 19.2 - 9. Compare food intoxication caused by Bacillus...
Ch. 19.2 - Prob. 2CYPCh. 19.2 - Prob. 3CYPCh. 19.2 - 4. What are the common elements of puncture...Ch. 19.2 - 5. What is the relationship between the normal...Ch. 19.2 - Prob. 6CYPCh. 19.2 - Prob. 7CYPCh. 19.2 - 8. ln what way is the ingested agent responsible...Ch. 19.3 - 10. Relate the severity of listeriosis with the...Ch. 19.3 - 11. Explain why people in certain occupations are...Ch. 19.3 - 9. Compare the effects of listeriosis in healthy...Ch. 19.3 - 10. Why do erysipeloids commonly appear on the...Ch. 19.4 - Prob. 12ELOCh. 19.4 - Prob. 13ELOCh. 19.4 - Prob. 11CYPCh. 19.4 - Prob. 12CYPCh. 19.5 - Prob. 14ELOCh. 19.5 - Prob. 15ELOCh. 19.5 - Prob. 16ELOCh. 19.5 - Prob. 17ELOCh. 19.5 - 18. Explain the significance of nontuberculous...Ch. 19.5 - Prob. 13CYPCh. 19.5 - 14. Compile a list of the advantages,...Ch. 19.5 - 15. Explain how and why antibacterial treatment...Ch. 19.5 - 16. List several differences between lepromatous...Ch. 19.5 - Prob. 17CYPCh. 19.5 - 18. List the diseases and at-risk populations...Ch. 19.6 - Prob. 19ELOCh. 19.6 - 20. Describe the types of infections attributable...Ch. 19.6 - 19. Compare the types of infections caused by the...Ch. 19.L1 - 1. What is/are the usual habitat(s) of...Ch. 19.L1 - Prob. 2MCQCh. 19.L1 - Prob. 3MCQCh. 19.L1 - 4. Clostridium perfringens causes a. myonecrosis...Ch. 19.L1 - Prob. 5MCQCh. 19.L1 - Prob. 6MCQCh. 19.L1 - Prob. 7MCQCh. 19.L1 - Prob. 8MCQCh. 19.L1 - Prob. 9MCQCh. 19.L1 - 10. Soil mycobacteria can be the cause of a....Ch. 19.L1 - Prob. 11MCQCh. 19.L1 - Prob. 12MCQCh. 19.L1 - Prob. 13MCQCh. 19.L1 - Prob. 14MCQCh. 19.L1 - Prob. 15MCQCh. 19.L1 - 16. Matching. Match the disease with the principal...Ch. 19.L1 - Prob. 1CSRCh. 19.L1 - 2. During this outbreak, some people sickened with...Ch. 19.L1 - 3. No listeria monocytogenes was discovered in the...Ch. 19.L1 - Prob. 1WCCh. 19.L1 - Prob. 2WCCh. 19.L1 - Prob. 3WCCh. 19.L1 - Prob. 4WCCh. 19.L1 - Prob. 5WCCh. 19.L1 - 6. a. Why is listeriosis a serious problem even...Ch. 19.L1 - Prob. 7WCCh. 19.L1 - Prob. 8WCCh. 19.L1 - 9. a. Outline the unique characteristics of...Ch. 19.L1 - Prob. 10WCCh. 19.L1 - 11. a. What is the importance of NTM? b. Describe...Ch. 19.L1 - Prob. 12WCCh. 19.L2 - Prob. 1CTCh. 19.L2 - 2. a. Why is it unlikely that diseases such as...Ch. 19.L2 - Prob. 3CTCh. 19.L2 - Prob. 4CTCh. 19.L2 - Prob. 5CTCh. 19.L2 - 6. Adequate cooking is the usual way to prevent...Ch. 19.L2 - 7. a. Why do patients who survive tetanus and...Ch. 19.L2 - Prob. 8CTCh. 19.L2 - 9. How can one tell that acne involves an...Ch. 19.L2 - Prob. 10CTCh. 19.L2 - Prob. 11CTCh. 19.L2 - Prob. 12CTCh. 19.L2 - 13. Which diseases discussed in this chapter have...Ch. 19.L2 - 14. Eighty-six people at a St. Patrick's Day...Ch. 19.L2 - 15. An outbreak of gastrointestinal illness was...Ch. 19.L2 - Prob. 1VCCh. 19.L2 - 2. From chapter 3, figure 3.8. What type of...
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