Human Biology (MindTap Course List)
11th Edition
ISBN: 9781305112100
Author: Cecie Starr, Beverly McMillan
Publisher: Cengage Learning
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Chapter 19, Problem 7CT
Summary Introduction
To explain: The probability that the children carry the sickle-cell trait and are sickle-cell anemic.
Introduction: Homozygous condition is when the same allele of a gene is present on both the homologous chromosomes either dominant or recessive. Heterozygous condition is where different alleles of the gene are present on both the homologous chromosomes where one is dominant and the other is recessive. Sickle-cell anemia occurs due to the homozygous recessive allele that changes the
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Suppose a woman who is a carrier of sickle-cell trait (making her a heterozygote) has children with a man who is totally healthy and does not carry the gene for sickle-cell trait at all. Which one of the following is true about their potential children? (Draw a Punnett square on scratch paper if it helps you.)
A) None of their children will have sickle-cell disease.
B) All of their children will have sickle-cell disease.
C) All of the couple's children would be heterozygous carriers like the mother.
Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype.
a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross.
b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
Given the information regarding sickle cell anemia, if two carriers were to have children, what would be the genotypes and phenotypes of their children? Would any of the children show symptoms of the disease?
Chapter 19 Solutions
Human Biology (MindTap Course List)
Ch. 19 - Define the difference between (a) gene and allele,...Ch. 19 - Prob. 2RQCh. 19 - What is probability, and how is it applied in...Ch. 19 - What is independent assortment? Does independent...Ch. 19 - Alleles are ___________. a. alternate forms of a...Ch. 19 - A heterozygote has _____. a. only one of the...Ch. 19 - Prob. 3SQCh. 19 - Offspring of a cross AA aa are ______. a. all AA...Ch. 19 - Prob. 5SQCh. 19 - Prob. 6SQ
Ch. 19 - Which statement best fits the principle of...Ch. 19 - Prob. 8SQCh. 19 - Prob. 9SQCh. 19 - Prob. 10SQCh. 19 - One gene has alleles A and a. Another has alleles...Ch. 19 - Still referring to Problem 1, what will be the...Ch. 19 - Go back to Problem 1, and assume you now study a...Ch. 19 - The young woman shown at right has albinismvery...Ch. 19 - When you decide to breed your Labrador retriever...Ch. 19 - The ABO blood system has been used to settle cases...Ch. 19 - Prob. 7CTCh. 19 - A man is homozygous dominant for ten different...Ch. 19 - Prob. 9CTCh. 19 - Bill and Marie each have flat feet, long...Ch. 19 - You decide to breed a pair of guinea pigs, one...
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- A woman with type A blood marries a man with type O blood. They have six children, all of whom have type A blood. What are the probable genotypes of the parents? Could they ever have a child with type O blood?arrow_forwardSickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?arrow_forwardA phenotypically normal man, who has a hemophiliac brother, marries a normal woman, who is not a carrier. What is the probability that any of their children will be hemophiliac?arrow_forward
- b) Figure 2 shows a family tree in which the blood group of certain individuals have been identified. 6. Figure 2 i) Identify the blood group of individual 2 and state your reason. ii) If Individual 6 marries a woman with the same blood group, state the phenotype of their children. iii) If Individual 6 has the same genotype with his grandfather, give the genotype of individual 5.arrow_forwardA person with type O blood is married to a person with type A blood (unknown genotype). They have 6 children, 3 of them have type A blood, three of them have type O blood. What is the genotype of the two parents?arrow_forwardHemophilia is a sex-linked recessive trait. A male hemophiliac and phenotypically normal female have a son with hemophilia. They would like to have one more child. What is the probability of having a child without hemophilia? Explain using a Punnett square. Is it possible for a girl to be born with hemophilia? Explain.arrow_forward
- A form of hemophilia is caused by a sex-linked (X-linked) recessive gene. A phenotypically normal woman whose father had hemophilia marries a man who suffers with hemophilia. What is the probability that their first daughter will have hemophilia?arrow_forwardSickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body. Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells. Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbAarrow_forwardSickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body. Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells. Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbAarrow_forward
- If a man with type O blood has a child with a woman who is heterozygous for type B blood, what are the possible blood types for this child?arrow_forwardIs the sickle cell allele dominant or recessive? Explain. What is sickle cell trait?arrow_forwardUsing the given pedigree chart, suppose individuals III-1 and III-2 are expecting their sixth child. What is the chance (percent) that the sixth child will have the sickle cell trait? arrow_forward
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