The logic behind the creation of a vaccine that targets host epithelial cell instead of viral antigens Introduction : Vaccination is a biological process in which an individual is immunized against a particular disease-causing agent in order to prevent the disease. The vaccine is prepared from a killed and weakened form of the pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual in order to induce the immune system against the microbes.

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Answer 1

Question

Chapter 19, Problem 6Q

Summary Introduction

To determine:

The logic behind the creation of a vaccine that targets host epithelial cell instead of viral antigens

Introduction:

Vaccination is a biological process in which an individual is immunized against a particular disease-causing agent in order to prevent the disease. The vaccine is prepared from a killed and weakened form of the pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual in order to induce the immune system against the microbes.

Summary Introduction

To determine:

The type of antigen that will come under such vaccine

Introduction:

Antigens are the substances that can initiate both humoral and cell-mediated immune responses. These are the substance that triggers the production of antibodies. Antibodies are secreted by the plasma cells through the differentiation of B lymphocytes. These antibodies are specific to a particular antigen. Antibodies produced by B cells provide a defense to the body. So, this type of immunity is called antibody-mediated immunity.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

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Answer 2

Question

Chapter 19, Problem 6Q

Summary Introduction

To determine:

The logic behind the creation of a vaccine that targets host epithelial cell instead of viral antigens

Introduction:

Vaccination is a biological process in which an individual is immunized against a particular disease-causing agent in order to prevent the disease. The vaccine is prepared from a killed and weakened form of the pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual in order to induce the immune system against the microbes.

Summary Introduction

To determine:

The type of antigen that will come under such vaccine

Introduction:

Antigens are the substances that can initiate both humoral and cell-mediated immune responses. These are the substance that triggers the production of antibodies. Antibodies are secreted by the plasma cells through the differentiation of B lymphocytes. These antibodies are specific to a particular antigen. Antibodies produced by B cells provide a defense to the body. So, this type of immunity is called antibody-mediated immunity.

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Answer 3

Question

Chapter 19, Problem 6Q

Summary Introduction

To determine:

The logic behind the creation of a vaccine that targets host epithelial cell instead of viral antigens

Introduction:

Vaccination is a biological process in which an individual is immunized against a particular disease-causing agent in order to prevent the disease. The vaccine is prepared from a killed and weakened form of the pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual in order to induce the immune system against the microbes.

Summary Introduction

To determine:

The type of antigen that will come under such vaccine

Introduction:

Antigens are the substances that can initiate both humoral and cell-mediated immune responses. These are the substance that triggers the production of antibodies. Antibodies are secreted by the plasma cells through the differentiation of B lymphocytes. These antibodies are specific to a particular antigen. Antibodies produced by B cells provide a defense to the body. So, this type of immunity is called antibody-mediated immunity.

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Answer 4

Question

Chapter 19, Problem 6Q

Summary Introduction

To determine:

The logic behind the creation of a vaccine that targets host epithelial cell instead of viral antigens

Introduction:

Vaccination is a biological process in which an individual is immunized against a particular disease-causing agent in order to prevent the disease. The vaccine is prepared from a killed and weakened form of the pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual in order to induce the immune system against the microbes.

Summary Introduction

To determine:

The type of antigen that will come under such vaccine

Introduction:

Antigens are the substances that can initiate both humoral and cell-mediated immune responses. These are the substance that triggers the production of antibodies. Antibodies are secreted by the plasma cells through the differentiation of B lymphocytes. These antibodies are specific to a particular antigen. Antibodies produced by B cells provide a defense to the body. So, this type of immunity is called antibody-mediated immunity.

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Answer 5

Chapter 19, Problem 6Q

Summary Introduction

To determine:

The logic behind the creation of a vaccine that targets host epithelial cell instead of viral antigens

Introduction:

Vaccination is a biological process in which an individual is immunized against a particular disease-causing agent in order to prevent the disease. The vaccine is prepared from a killed and weakened form of the pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual in order to induce the immune system against the microbes.

Summary Introduction

To determine:

The type of antigen that will come under such vaccine

Introduction:

Antigens are the substances that can initiate both humoral and cell-mediated immune responses. These are the substance that triggers the production of antibodies. Antibodies are secreted by the plasma cells through the differentiation of B lymphocytes. These antibodies are specific to a particular antigen. Antibodies produced by B cells provide a defense to the body. So, this type of immunity is called antibody-mediated immunity.

Answer 6

Chapter 19, Problem 6Q

Summary Introduction

To determine:

The logic behind the creation of a vaccine that targets host epithelial cell instead of viral antigens

Introduction:

Vaccination is a biological process in which an individual is immunized against a particular disease-causing agent in order to prevent the disease. The vaccine is prepared from a killed and weakened form of the pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual in order to induce the immune system against the microbes.

Answer 7

Chapter 19, Problem 6Q

Summary Introduction

To determine:

The logic behind the creation of a vaccine that targets host epithelial cell instead of viral antigens

Introduction:

Vaccination is a biological process in which an individual is immunized against a particular disease-causing agent in order to prevent the disease. The vaccine is prepared from a killed and weakened form of the pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual in order to induce the immune system against the microbes.

Answer 8

Summary Introduction

To determine:

The type of antigen that will come under such vaccine

Introduction:

Antigens are the substances that can initiate both humoral and cell-mediated immune responses. These are the substance that triggers the production of antibodies. Antibodies are secreted by the plasma cells through the differentiation of B lymphocytes. These antibodies are specific to a particular antigen. Antibodies produced by B cells provide a defense to the body. So, this type of immunity is called antibody-mediated immunity.

Answer 9

Summary Introduction

To determine:

The type of antigen that will come under such vaccine

Introduction:

Antigens are the substances that can initiate both humoral and cell-mediated immune responses. These are the substance that triggers the production of antibodies. Antibodies are secreted by the plasma cells through the differentiation of B lymphocytes. These antibodies are specific to a particular antigen. Antibodies produced by B cells provide a defense to the body. So, this type of immunity is called antibody-mediated immunity.

Answer 10

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Answer 13

Ch. 19.1 - Draw or describe the anatomical features of the...Ch. 19.1 - Prob. 2AYP Ch. 19.2 - List the types of normal biota presently known to...Ch. 19.2 - Prob. 1MM Ch. 19.3 - List the possible causative agents, modes of...Ch. 19.3 - Identify the most dangerous cause of pharyngitis...Ch. 19.3 - Prob. 6AYP Ch. 19.3 - Prob. 1NP Ch. 19.3 - Prob. 2NP Ch. 19.3 - Prob. 3NP

Solution Summary: The author explains that a vaccine that targets the host epithelial cell instead of viral antigens is called antibody-mediated immunity.

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