To examine: Whether the statement “given the numerous processes inside cells that are regulated by changes in Ca +2 concentration, it seems likely that Ca +2 -dependent cell-cell adhesions are also regulated by changes in Ca +2 concentration” is true or false. Introduction: Cell-cell adhesions play an important role in maintaining the architecture of various tissues. The homophilic and heterophilic adhesion of cells is mediated by many cell-surface proteins (CAMs). CAMs are classified into five categories- cadherins, immunoglobulins, mucins, integrins, and selectins. Out of these, cadherin and selectin based cell adhesions depend on Ca +2 concentration.

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Answer 1

Question

Chapter 19, Problem 1P

Summary Introduction

To examine: Whether the statement “given the numerous processes inside cells that are regulated by changes in Ca⁺² concentration, it seems likely that Ca⁺²-dependent cell-cell adhesions are also regulated by changes in Ca⁺² concentration” is true or false.

Introduction:

Cell-cell adhesions play an important role in maintaining the architecture of various tissues. The homophilic and heterophilic adhesion of cells is mediated by many cell-surface proteins (CAMs). CAMs are classified into five categories- cadherins, immunoglobulins, mucins, integrins, and selectins. Out of these, cadherin and selectin based cell adhesions depend on Ca⁺² concentration.

Expert Solution & Answer

Answer to Problem 1P

Correct answer: The statement is false.

Explanation of Solution

The regulation of various cell-cell interactions and processes are mediated by changes in Ca⁺² concentration through Ca⁺² signaling pathways. Cell surface proteins (CAMs) contribute in cell-cell adhesions. Cadherins come under Ca⁺²-dependent CAMs. The N-terminal extracellular domain is the site for binding of Ca⁺² and thus, adhesion of cells. The removal of Ca⁺² from extracellular medium dissociates the cells causing cadherins to mediate cell-cell adhesion. The cell-cell adhesion is not regulated by Ca⁺² concentration changes as cells cannot control Ca⁺² concentration in their environment. Hence, the statement is false.

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Answer 2

Question

Chapter 19, Problem 1P

Summary Introduction

To examine: Whether the statement “given the numerous processes inside cells that are regulated by changes in Ca⁺² concentration, it seems likely that Ca⁺²-dependent cell-cell adhesions are also regulated by changes in Ca⁺² concentration” is true or false.

Introduction:

Cell-cell adhesions play an important role in maintaining the architecture of various tissues. The homophilic and heterophilic adhesion of cells is mediated by many cell-surface proteins (CAMs). CAMs are classified into five categories- cadherins, immunoglobulins, mucins, integrins, and selectins. Out of these, cadherin and selectin based cell adhesions depend on Ca⁺² concentration.

Expert Solution & Answer

Answer to Problem 1P

Correct answer: The statement is false.

Explanation of Solution

The regulation of various cell-cell interactions and processes are mediated by changes in Ca⁺² concentration through Ca⁺² signaling pathways. Cell surface proteins (CAMs) contribute in cell-cell adhesions. Cadherins come under Ca⁺²-dependent CAMs. The N-terminal extracellular domain is the site for binding of Ca⁺² and thus, adhesion of cells. The removal of Ca⁺² from extracellular medium dissociates the cells causing cadherins to mediate cell-cell adhesion. The cell-cell adhesion is not regulated by Ca⁺² concentration changes as cells cannot control Ca⁺² concentration in their environment. Hence, the statement is false.

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Answer 3

Question

Chapter 19, Problem 1P

Summary Introduction

To examine: Whether the statement “given the numerous processes inside cells that are regulated by changes in Ca⁺² concentration, it seems likely that Ca⁺²-dependent cell-cell adhesions are also regulated by changes in Ca⁺² concentration” is true or false.

Introduction:

Cell-cell adhesions play an important role in maintaining the architecture of various tissues. The homophilic and heterophilic adhesion of cells is mediated by many cell-surface proteins (CAMs). CAMs are classified into five categories- cadherins, immunoglobulins, mucins, integrins, and selectins. Out of these, cadherin and selectin based cell adhesions depend on Ca⁺² concentration.

Expert Solution & Answer

Answer to Problem 1P

Correct answer: The statement is false.

Explanation of Solution

The regulation of various cell-cell interactions and processes are mediated by changes in Ca⁺² concentration through Ca⁺² signaling pathways. Cell surface proteins (CAMs) contribute in cell-cell adhesions. Cadherins come under Ca⁺²-dependent CAMs. The N-terminal extracellular domain is the site for binding of Ca⁺² and thus, adhesion of cells. The removal of Ca⁺² from extracellular medium dissociates the cells causing cadherins to mediate cell-cell adhesion. The cell-cell adhesion is not regulated by Ca⁺² concentration changes as cells cannot control Ca⁺² concentration in their environment. Hence, the statement is false.

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Answer 4

Question

Chapter 19, Problem 1P

Summary Introduction

To examine: Whether the statement “given the numerous processes inside cells that are regulated by changes in Ca⁺² concentration, it seems likely that Ca⁺²-dependent cell-cell adhesions are also regulated by changes in Ca⁺² concentration” is true or false.

Introduction:

Cell-cell adhesions play an important role in maintaining the architecture of various tissues. The homophilic and heterophilic adhesion of cells is mediated by many cell-surface proteins (CAMs). CAMs are classified into five categories- cadherins, immunoglobulins, mucins, integrins, and selectins. Out of these, cadherin and selectin based cell adhesions depend on Ca⁺² concentration.

Expert Solution & Answer

Answer to Problem 1P

Correct answer: The statement is false.

Explanation of Solution

The regulation of various cell-cell interactions and processes are mediated by changes in Ca⁺² concentration through Ca⁺² signaling pathways. Cell surface proteins (CAMs) contribute in cell-cell adhesions. Cadherins come under Ca⁺²-dependent CAMs. The N-terminal extracellular domain is the site for binding of Ca⁺² and thus, adhesion of cells. The removal of Ca⁺² from extracellular medium dissociates the cells causing cadherins to mediate cell-cell adhesion. The cell-cell adhesion is not regulated by Ca⁺² concentration changes as cells cannot control Ca⁺² concentration in their environment. Hence, the statement is false.

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Answer 5

Chapter 19, Problem 1P

Summary Introduction

To examine: Whether the statement “given the numerous processes inside cells that are regulated by changes in Ca⁺² concentration, it seems likely that Ca⁺²-dependent cell-cell adhesions are also regulated by changes in Ca⁺² concentration” is true or false.

Introduction:

Cell-cell adhesions play an important role in maintaining the architecture of various tissues. The homophilic and heterophilic adhesion of cells is mediated by many cell-surface proteins (CAMs). CAMs are classified into five categories- cadherins, immunoglobulins, mucins, integrins, and selectins. Out of these, cadherin and selectin based cell adhesions depend on Ca⁺² concentration.

Expert Solution & Answer

Answer to Problem 1P

Correct answer: The statement is false.

Explanation of Solution

The regulation of various cell-cell interactions and processes are mediated by changes in Ca⁺² concentration through Ca⁺² signaling pathways. Cell surface proteins (CAMs) contribute in cell-cell adhesions. Cadherins come under Ca⁺²-dependent CAMs. The N-terminal extracellular domain is the site for binding of Ca⁺² and thus, adhesion of cells. The removal of Ca⁺² from extracellular medium dissociates the cells causing cadherins to mediate cell-cell adhesion. The cell-cell adhesion is not regulated by Ca⁺² concentration changes as cells cannot control Ca⁺² concentration in their environment. Hence, the statement is false.

Answer 6

Chapter 19, Problem 1P

Summary Introduction

To examine: Whether the statement “given the numerous processes inside cells that are regulated by changes in Ca⁺² concentration, it seems likely that Ca⁺²-dependent cell-cell adhesions are also regulated by changes in Ca⁺² concentration” is true or false.

Introduction:

Cell-cell adhesions play an important role in maintaining the architecture of various tissues. The homophilic and heterophilic adhesion of cells is mediated by many cell-surface proteins (CAMs). CAMs are classified into five categories- cadherins, immunoglobulins, mucins, integrins, and selectins. Out of these, cadherin and selectin based cell adhesions depend on Ca⁺² concentration.

Expert Solution & Answer

Answer to Problem 1P

Correct answer: The statement is false.

Explanation of Solution

The regulation of various cell-cell interactions and processes are mediated by changes in Ca⁺² concentration through Ca⁺² signaling pathways. Cell surface proteins (CAMs) contribute in cell-cell adhesions. Cadherins come under Ca⁺²-dependent CAMs. The N-terminal extracellular domain is the site for binding of Ca⁺² and thus, adhesion of cells. The removal of Ca⁺² from extracellular medium dissociates the cells causing cadherins to mediate cell-cell adhesion. The cell-cell adhesion is not regulated by Ca⁺² concentration changes as cells cannot control Ca⁺² concentration in their environment. Hence, the statement is false.

Answer 7

Chapter 19, Problem 1P

Summary Introduction

To examine: Whether the statement “given the numerous processes inside cells that are regulated by changes in Ca⁺² concentration, it seems likely that Ca⁺²-dependent cell-cell adhesions are also regulated by changes in Ca⁺² concentration” is true or false.

Introduction:

Cell-cell adhesions play an important role in maintaining the architecture of various tissues. The homophilic and heterophilic adhesion of cells is mediated by many cell-surface proteins (CAMs). CAMs are classified into five categories- cadherins, immunoglobulins, mucins, integrins, and selectins. Out of these, cadherin and selectin based cell adhesions depend on Ca⁺² concentration.

Answer 8

Expert Solution & Answer

Answer to Problem 1P

Correct answer: The statement is false.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Explanation of Solution

The regulation of various cell-cell interactions and processes are mediated by changes in Ca⁺² concentration through Ca⁺² signaling pathways. Cell surface proteins (CAMs) contribute in cell-cell adhesions. Cadherins come under Ca⁺²-dependent CAMs. The N-terminal extracellular domain is the site for binding of Ca⁺² and thus, adhesion of cells. The removal of Ca⁺² from extracellular medium dissociates the cells causing cadherins to mediate cell-cell adhesion. The cell-cell adhesion is not regulated by Ca⁺² concentration changes as cells cannot control Ca⁺² concentration in their environment. Hence, the statement is false.

Answer 12

Ch. 19 - Prob. 1P Ch. 19 - Prob. 2P Ch. 19 - Prob. 3P Ch. 19 - Prob. 4P Ch. 19 - Prob. 5P Ch. 19 - Prob. 6P Ch. 19 - Prob. 7P Ch. 19 - Prob. 8P Ch. 19 - Prob. 9P Ch. 19 - Prob. 10P

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