Chapter 19, Problem 19.83CP

Interpretation Introduction

Interpretation:

The way to distinguish between a competitive inhibitor and an uncompetitive inhibitor experimentally should be given.

Concept Introduction:

Enzyme inhibitors: The substance which slows or stops the action of an enzyme is called enzyme inhibitors.

It can be used as drugs and an example is AZT which is used to treat HIV.

The competition of an enzyme can be reversible or irreversible and in reversible inhibition, the inhibitor can leave and in irreversible inhibition, the inhibitor remains permanently bound.

Reversible Competitive inhibition: It is a type of inhibition occurs when the inhibitor resembles very much to the substrate and thus prevents the substrate binding.

Reversible uncompetitive inhibition: It is a type of enzyme regulation in which an inhibitor binds reversibly to the enzyme-substrate complex and thereby blocking the binding of the second substrate to the binding site.

Irreversible competitive inhibition: It is a type of inhibition in which an inhibitor forms covalent bonds to the active site and thereby permanently blocking it.