A synthesis of nifedipine from 2-nitrobenzaldehyde, methyl acetoacetate and ammonia has to be given. Concept introduction: Aldol condensation: Aldol reaction is an addition reaction of aldehydes and ketones . Aldol reaction is a reversible reaction and occurs in the presence of a strong base like sodium hydroxide. One molecule (aldehyde or ketone) acts a nucleophile and attacks the electrophilic carbon center of the other molecule to give the addition product. The product is named β -hydroxy aldehyde if two aldehydes combine and β -hydroxy ketone if two ketones combine. Michael reaction: The reaction occurs with a variety of α,β -unsaturated carbonyl compounds such as aldehydes, esters, nitriles, nitro compounds and amides. The donor compound of this reaction includes β -diketones, β -keto nitriles, β -keto esters.

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Answer 1

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19, Problem 19.55P

Interpretation Introduction

Interpretation:

A synthesis of nifedipine from 2-nitrobenzaldehyde, methyl acetoacetate and ammonia has to be given.

Concept introduction:

Aldol condensation:

Aldol reaction is an addition reaction of aldehydes and ketones. Aldol reaction is a reversible reaction and occurs in the presence of a strong base like sodium hydroxide. One molecule (aldehyde or ketone) acts a nucleophile and attacks the electrophilic carbon center of the other molecule to give the addition product. The product is named β-hydroxy aldehyde if two aldehydes combine and β-hydroxy ketone if two ketones combine.

Michael reaction:

The reaction occurs with a variety of α,β-unsaturated carbonyl compounds such as aldehydes, esters, nitriles, nitro compounds and amides.

The donor compound of this reaction includes β-diketones, β-keto nitriles, β-keto esters.

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am os Д Br

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Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19, Problem 19.55P

Interpretation Introduction

Interpretation:

A synthesis of nifedipine from 2-nitrobenzaldehyde, methyl acetoacetate and ammonia has to be given.

Concept introduction:

Aldol condensation:

Aldol reaction is an addition reaction of aldehydes and ketones. Aldol reaction is a reversible reaction and occurs in the presence of a strong base like sodium hydroxide. One molecule (aldehyde or ketone) acts a nucleophile and attacks the electrophilic carbon center of the other molecule to give the addition product. The product is named β-hydroxy aldehyde if two aldehydes combine and β-hydroxy ketone if two ketones combine.

Michael reaction:

The reaction occurs with a variety of α,β-unsaturated carbonyl compounds such as aldehydes, esters, nitriles, nitro compounds and amides.

The donor compound of this reaction includes β-diketones, β-keto nitriles, β-keto esters.

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Check out sample textbook solution

Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19, Problem 19.55P

Interpretation Introduction

Interpretation:

A synthesis of nifedipine from 2-nitrobenzaldehyde, methyl acetoacetate and ammonia has to be given.

Concept introduction:

Aldol condensation:

Aldol reaction is an addition reaction of aldehydes and ketones. Aldol reaction is a reversible reaction and occurs in the presence of a strong base like sodium hydroxide. One molecule (aldehyde or ketone) acts a nucleophile and attacks the electrophilic carbon center of the other molecule to give the addition product. The product is named β-hydroxy aldehyde if two aldehydes combine and β-hydroxy ketone if two ketones combine.

Michael reaction:

The reaction occurs with a variety of α,β-unsaturated carbonyl compounds such as aldehydes, esters, nitriles, nitro compounds and amides.

The donor compound of this reaction includes β-diketones, β-keto nitriles, β-keto esters.

Expert Solution & Answer

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See solution

Check out sample textbook solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19, Problem 19.55P

Interpretation Introduction