Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 19, Problem 12PIAT
Summary Introduction
To review:
The activity of the enhancer that regulates the transcription of the gene located far from the gene.
Introduction:
An enhancer is a regulatory sequence on the deoxyribonucleic acid (DNA). It is located far from the promoter base sequence. In eukaryotes, they also assist in initiating transcription like the core promoter sequence. They get associated with transcriptional factors, which are proteins during initiation of transcription.
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Enhancers can influence the transcription of genes far away on the same chromosome. How are the effects of enhancers restricted so that they do not exert inappropriate transcriptional activation of non-target genes?
What is an enhancer? How does it affect the transcription of distant genes?
How can binding of activators to an enhancer located far from the promoter influence transcription?
Chapter 19 Solutions
Biological Science (7th Edition)
Ch. 19 - What is chromatin? a. the histone-containing...Ch. 19 - Prob. 4TYKCh. 19 - Compare and contrast the items in each pair: (a)...Ch. 19 - Prob. 6TYUCh. 19 - Prob. 8TYUCh. 19 - Prob. 9TYPSSCh. 19 - 10. QUANTITATIVE Imagine repeating the experiment...Ch. 19 - Prob. 12PIATCh. 19 - Prob. 13PIATCh. 19 - Prob. 14PIAT
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- How are the actions of lac repressor and trp repressor similar and how are they different with regard to their binding to operator sites, their effects on transcription, and the influences of small effector molecules?arrow_forwardPlease compare the effect of an active enhancer at the level of RNA transcription with the effect of an active enhancer at the level of RNA splicingarrow_forwardHow does binding of the trp corepressor to the trp repressor alter repressor function and transcription? What about the binding of the lac inducer to the lac repressor?arrow_forward
- What are general transcription factors? When do you expect to find them? What is a cis acting regulatory sequence? Where are they located in comparison with the gene they are regulating?arrow_forwardHow would a mutation which prevented Gal3 from binding to Gal80 affect gene expression from the GAL promoter?arrow_forwardHow enhancers influence transcription of eukaryotic genes ?arrow_forward
- Through alternative splicing, eukaryotes (a) reinforce gene inactivation (b) prevent transcription of heterochromatin (c) produce related but different proteins in different tissues (d) amplify genes to meet the requirement of high levels of a gene product (e) bind transcription factors to enhancers to activate transcriptionarrow_forwardAn enhancer is surrounded by four genes (A, B, C, and D), as shown in the accompanying diagram. An insulator lies between gene C and gene D. On the basis of the positions of the genes, the enhancer, and the insulator, the transcription of which genes is most likely to be stimulated by the enhancer? Explain your reasoning.arrow_forwardWhat is an enhancer? What do these sequences contain bound to it? Do enhancers have to be near promoters?arrow_forward
- What are allosteric RNA leaders that bind small molecule effectors to control gene expression?arrow_forwardWhat is the mechanism of transcription attenuation?arrow_forwardWhat role does an operator sequence serve in bacterial gene expression regulation? Describe one change in bacterial cells that can cause a repressor protein to go from inactive to active or from active to inactive.arrow_forward
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