Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 19, Problem 4TYK
Summary Introduction
Introduction:
Splicing refers to the editing of the precursor mRNA (messenger ribonucleic acid) and to transcript it into mature messenger mRNA. The introns are removed and exons are ligated together, after the splicing process.
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If an MRNA is alternatively spliced, then
different introns are removed from a pre-MRNA, producing transcripts that will potentially encode proteins with different primary structures.
I.
the MRNA is found in a bacterial cell.
II.
transcription and translation of the MRNA will occur simultaneously.
the alternative splicing happened in the cytoplasm.
IV.
Ay different exons from a pre-mRNA will be spliced together.
V.
the different MRNAS will all have poly-A tails.
VI.
Researchers are designing and testing antisense drugs as therapies for a variety of diseases, inclusing cancer, AIDS, diabeates, and muscular dystrophy. The drugs are also being tested to fight infection by deadly viruses such as Ebola. Antisense drugs consist of short RNA strands coplementary in sequence to mRNAs that form during the progression of a disease. How do you think these drugs work?
Arrange the statements in their proper order by writing the corresponding letter
(e.g. A) for each statement in the space provided below.
A. The single-stranded RNA would complement the target RNA.
B. Gene expression is inactivated once the mRNA is no longer accessible for
translation.
C. The risk-induced silencing complex which is composed of RNA and protein
subunits is formed.
D. Double-stranded, non-coding RNA is cleaved by Dicer.
E. The mRNA can be cleaved or remain bound by the RISC.
1.
2.
3.
4.
5.
Chapter 19 Solutions
Biological Science (7th Edition)
Ch. 19 - What is chromatin? a. the histone-containing...Ch. 19 - Prob. 4TYKCh. 19 - Compare and contrast the items in each pair: (a)...Ch. 19 - Prob. 6TYUCh. 19 - Prob. 8TYUCh. 19 - Prob. 9TYPSSCh. 19 - 10. QUANTITATIVE Imagine repeating the experiment...Ch. 19 - Prob. 12PIATCh. 19 - Prob. 13PIATCh. 19 - Prob. 14PIAT
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- Alternate splicing: A. Reduces mRNA half-life by shortening poly(A) tails B. Disrupts histone arrangement for increased transcription C. Uses topoisomerase to complete its function D. Can produce 2 or more products from one genearrow_forwardDuring RNA splicing a. All exons are removed and degraded in the cell b. mRNA is made from DNA template c. Introns are removed from the mRNA and the exons are spliced together d. mRNA is translated into a protein moleculearrow_forwardWhat is the purpose of alternative splicing a. Alternative spiicing allows a protein to be included by multiple genes b. Alternative spicing allows for mutations to accumulate that won't affect the expression of a gene c. Alternative splicing allows for multiple mRNAs to be produced to ensure that the single proteins the gene and codes will be translated. d.arrow_forward
- Which of the following is an example of chromatin modification that stimulates gene expression? Group of answer choices A. alternative exon splicing b. microRNA binding to mRNA c. DNA methylation D. histone acetylationarrow_forwardHow does reverse methylation affect gene expression? Select one: o a. The gene is turned off, but still expresses a protein product. b. The gene becomes transcriptionally silent. c. There is no effect on the gene. d. The gene is hyperactive resulting in a gain of function. e. The gene expresses the wrong protein. Clear my choice How do microRNAs regulate epigenetic mechanisms during development? Select one: o a. MicroRNAs function as gene repressors b. You only find microRNAS in epigenetic and cancer cells c. MicroRNAs function as gene activators d. MicroRNAS regulate methylation on the DNA sequences of embryos e. Researchers find that when microRNAs are present the effects of epigenetic modifications are 50% greater Clear my choicearrow_forwardQ1: In your own words, define RNA splicing. When during gene expression does it occur? Q2: What do you predict would happen if the introns were not removed from RNA before translation? Why would it be a problem if the introns were not removed? Q3: Where is the mRNA destined to go once it has been transported out of the nucleus?arrow_forward
- Researchers are designing and testing antisense drugs as therapies for a variety of diseases, including cancer, AIDS, diabetes, and muscular dystrophy. The drugs are also being tested to fight infection by deadly viruses such as Ebola. Antisense drugs consist of short RNA strands complementary in sequence to mRNAs that form during the progression of a disease. How do you think these drugs work?arrow_forwardTranscriptional repressor proteins (e.g., lac repressor), antisense RNA, and feedback inhibition are three different mechanisms that turn off the expression of genes and gene products. Which of these three mechanisms will be most effective in each of the following situations? A. Shutting down the synthesis of a polypeptide B. Shutting down the synthesis of mRNA C. Shutting off the function of a protein For your answers to parts A–C that list more than one mechanism, which mechanism will be the fastest or the most efficient?arrow_forwardYou are studying how gene expression is regulated in the cell. For gene z, you find that while there are high levels of mRNA in the cell, there are low levels of the protein encoded by gene z. Describe a regulatory mechanism that could explain this finding that occurs after translation.arrow_forward
- Alternative splicing allows for more proteins to be made from the same region of DNA; explain how you can get multiple proteins from the same DNA. Then explain if alternative splicing changes the DNA and/or the mRNA. Draw or diagram out an image to depict this.arrow_forwardIf a cell's DNA was mutated such that it lost the promoter of a gene, you would expect: a. That ribosomes wouldn’t bind to that gene b. No effect since the promoter doesn't have any coding information for the amino acids in the polypeptide c. Ribosomes would never stop translating that gene d. Transcription factors for that gene would no longer bind to activate expression of that gene e. tRNA would no longer bind to the codons of that genearrow_forwardExplain how each of the following processes complicates the concept of colinearity. a. Trans-splicing b. Alternative splicing c. RNA editingarrow_forward
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