Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 19, Problem 11P
Summary Introduction

a.

To determine:

The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin.

Introduction:

The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G1, S, G2, and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

Summary Introduction

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

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