Foundations in Microbiology
9th Edition
ISBN: 9780073522609
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 18.L1, Problem 2WC
What conditions favor staph food poisoning?
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Match the letter labels in the figure below to the terms. Some letter
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M
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B
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The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
There is currently a H5N1 cattle outbreak in North America.
According to the CDC on Feb 26*: "A multistate outbreak of HPAI A(H5N1) bird flu in dairy cows was first reported on March 25, 2024. This is the first time that these bird flu viruses had been found in cows. In the United States, since 2022, USDA has reported HPAI A(H5N1) virus detections in more than 200 mammals."
List and describe two mechanisms that could lead to this H5N1 influenza strain evolving to spread in human:
Mechanisms 1:
Mechanisms 2:
For the mutations to results in a human epidered they would need to change how the virus interacts with the human host. In the case of mutations that may promote an epidemic, provide an example for:
a protein that might incur a mutation:
how the mutation would change interactions with cells in the respiratory tract (name the receptor on human cells)
List two phenotypic consequence from this mutation that would increase human risk
Chapter 18 Solutions
Foundations in Microbiology
Ch. 18.1 - Prob. 1ELOCh. 18.1 - Describe the ability of S. aureus to withstand...Ch. 18.1 - Prob. 3ELOCh. 18.1 - Summarize the cutaneous, systemic, and toxigenic...Ch. 18.1 - Prob. 5ELOCh. 18.1 - Explain strategies used to prevent and treat...Ch. 18.1 - Prob. 1CYPCh. 18.1 - Discuss why food intoxication in salty foods, such...Ch. 18.1 - Explain how unbroken skin, the phagocytic action...Ch. 18.1 - List the strategies commonly used to prevent and...
Ch. 18.1 - Explain the meanings of the acronyms MRSA, VRE,...Ch. 18.2 - Name the most important human pathogens in the...Ch. 18.2 - Summarize the virulence factors of S. pyogenes, as...Ch. 18.2 - Prob. 9ELOCh. 18.2 - Explain strategies used to prevent and treat...Ch. 18.2 - Relate the pathogenesis and epidemiology of S....Ch. 18.2 - List the clinically significant pathogens in the...Ch. 18.2 - Describe the immediate effects and long-term...Ch. 18.2 - Prob. 8CYPCh. 18.2 - Differentiate between pneumococcal disease...Ch. 18.3 - Name the most important human pathogens in the...Ch. 18.3 - Compare the differences in pathologies of N....Ch. 18.3 - Summarize the pathogenesis and epidemiology of N....Ch. 18.3 - Recall the medically important genera, besides...Ch. 18.3 - Describe the epidemiology and pathology of N....Ch. 18.3 - List the short-term and long-term consequences of...Ch. 18.3 - Prob. 12CYPCh. 18.L1 - Which of the following is/are a pyogenic...Ch. 18.L1 - The coagulase text is used primarily to...Ch. 18.L1 - Prob. 3MCQCh. 18.L1 - The most severe streptococcal diseases are caused...Ch. 18.L1 - 5. Rheumatic fever damages the _______, and...Ch. 18.L1 - ______ hemolysis is the partial lysis of red blood...Ch. 18.L1 - Prob. 7MCQCh. 18.L1 - Which of the following strains of pathogens has...Ch. 18.L1 - Otitis media is a/an _______ infection often...Ch. 18.L1 - Prob. 10MCQCh. 18.L1 - Prob. 11MCQCh. 18.L1 - Prob. 12MCQCh. 18.L1 - Prob. 13MCQCh. 18.L1 - Which infectious agent of those covered in the...Ch. 18.L1 - Prob. 15MCQCh. 18.L1 - Prob. 16MCQCh. 18.L1 - The first step in the clinical diagnosis of...Ch. 18.L1 - Vaccination can provide protection against N....Ch. 18.L1 - In this case, the first step taken to treat...Ch. 18.L1 - Prob. 1WCCh. 18.L1 - What conditions favor staph food poisoning?Ch. 18.L1 - Prob. 3WCCh. 18.L1 - Prob. 4WCCh. 18.L1 - Discuss the apparent pathology at work in...Ch. 18.L1 - Prob. 6WCCh. 18.L1 - a. Compare and contrast the characteristics of...Ch. 18.L2 - You have been handed the problem of diagnosing...Ch. 18.L2 - You have been called upon to prevent outbreaks of...Ch. 18.L2 - Prob. 3CTCh. 18.L2 - Prob. 4CTCh. 18.L2 - Prob. 5CTCh. 18.L2 - Prob. 6CTCh. 18.L2 - Prob. 1VCCh. 18.L2 - Prob. 2VC
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