Essential Cell Biology (Fourth Edition)
Essential Cell Biology (Fourth Edition)
4th Edition
ISBN: 9780815345251
Author: Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D. Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 18, Problem 6Q
Summary Introduction

To explain: The mechanism by which the kinetochore is normally attached to the microtubules in order to push the chromosome apart during cell division from an experiment.

Introduction: Kinetochores are protein complexes that assemble around the centromere of the condensed mitotic chromosome where the spindle microtubules will attach to.  The microtubule can attach itself to the kinetochore randomly. There are three possible ways of attachment of the kinetochore with microtubule: amphitelic attachment where two microtubules from opposite poles attach to two kinetochores each; merotelic attachment where two microtubules from opposite poles attach to the same kinetochore; syntelic attachment where microtubule from one pole attaches to two different kinetochores; and monotelic attachment where one microtubule from one pole attaches to one kinetochore.

Summary Introduction

To explain: The observation about the attachment of the kinetochore that is programmed to attach to microtubules from a particular pole.

Introduction: Kinetochores are protein complexes that assemble around the centromere of the condensed mitotic chromosome where the spindle microtubules will attach to.  The microtubule can attach itself to the kinetochore randomly. There are three possible ways of attachment of the kinetochore with microtubule: amphitelic attachment where two microtubules from opposite poles attach to two kinetochores each; merotelic attachment where two microtubules from opposite poles attach to the same kinetochore; syntelic attachment where microtubule from one pole attaches to two different kinetochores; and monotelic attachment where one microtubule from one pole attaches to one kinetochore.

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