Chapter 18, Problem 5CP

Summary Introduction

To analyze:

The method by which the presence of the substance that inhibits the enzyme adenylate cyclase affects the activity of a hormone that produces its cellular effects by way of the second messenger $\text{cAMP}$.

Introduction:

The hormone binds to the receptor on the surface of the cell. This causes the activation of cell signaling cascade. The enzyme adenylyl or adenylate cyclase converts the ATP into the second messenger $\text{cAMP}$. This activates the kinase phosphorylation cascade inside the cell. The enzyme phosphodiesterase converts $\text{cAMP}$ into AMP, which causes the inactivation or inhibition of the cell signaling cascade.