Nester's Microbiology: A Human Perspective
Nester's Microbiology: A Human Perspective
8th Edition
ISBN: 9780073522593
Author: Denise G. Anderson Lecturer, Sarah Salm, Deborah Allen
Publisher: McGraw-Hill Education
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Chapter 18, Problem 2CT
Summary Introduction

To review:

The way in which a protein A made by Staphylococcus aureus can be exploited in immunoassays.

Introduction:

Staphylococcus aureus surface protein A is a 42 Da (Dalton) protein, which is composed of 2271 amino acids and belongs to serine-rich repeat proteins family. Protein A is encoded by the spa gene. It is used in research because of its ability to bind with the immunoglobulin. It is composed of five immunoglobulin domain that folds into a three-helix bundle. It binds to the heavy chain that is present in the Fc (fragment crystallizable) region of most of the most immunoglobulins.

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