Genetics: From Genes To Genomes (6th International Edition)
6th Edition
ISBN: 9781260041217
Author: Leland Hartwell Dr., ? Michael L. Goldberg Professor Dr., ? Janice Fischer, ? Leroy Hood Dr.
Publisher: Mcgraw-Hill
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Chapter 18, Problem 24P
| a. | Figures 18.9 and 18.12 demonstrated methods to produce mouse knockouts and knockins, respectively.CRISPR/Cas9 can make the same knockouts and knockins, and most mouse geneticists would now choose to use this new technology instead of the other methods. Explain why, respectively CRISPR/Cas9 is an easier and more efficient way to perform targeted mutagenesis in mice. |
| b. | How could you use the CRISPR/Cas9 technique to obtain a conditional knockout of a gene’s function only in a specific tissue of a multicellular organism?  |
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9. Chicken combs in chickens is an example where you see interactions between genes.
See potential genotypes and phenotypes below. Which genotype, when mated to a
rose comb chicken, will produce progeny that are 50% walnut comb and 50% pea comb?
walnut
(RRPP)
walnut
(RrPP)
pea
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walnut
(RRPP)
walnut
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pea
(rrPp)
rose
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(RRPP)
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(rrpp)
Describe a compound light microscope and its importance in microbiology (2) examples of at least two microbes viewed under a compound light microscope and their general characteristics (note: the microbes you choose do not need to be the ones outlined in the above tutorial video) and (3) at least one source you used for the information included in your infographic.
Chapter 18 Solutions
Genetics: From Genes To Genomes (6th International Edition)
Ch. 18 - Match each of the terms in the left column to the...Ch. 18 - Mice are usually gray, but a mouse geneticist has...Ch. 18 - Sometimes, genes transferred into the mouse genome...Ch. 18 - In mice, a group of so-called Hox genes encode...Ch. 18 - The fly eyes shown in Fig. 18.7 are malformed...Ch. 18 - This problem concerns a technique called enhancer...Ch. 18 - Fish and other organisms that live in the Arctic...Ch. 18 - a. Describe two ways you could potentially make a...Ch. 18 - Figure 18.6 shows a picture of Glofish ,...Ch. 18 - Some people are concerned about the possible...
Ch. 18 - The goal of the Knockout Mouse Project is to...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - a. Which genome manipulation technique would you...Ch. 18 - a. Diagram a knockin construct that could have...Ch. 18 - Prob. 16PCh. 18 - Prob. 17PCh. 18 - The transcription factor Pax6 is required...Ch. 18 - Mouse models for human genetic diseases are...Ch. 18 - One way to determine where inside a cell a protein...Ch. 18 - In Problem 5 in Chapter 17, you saw that a SNP...Ch. 18 - Scientists now routinely use CRISPR/Cas9 to make...Ch. 18 - Geneticists are currently considering using...Ch. 18 - a. Figures 18.9 and 18.12 demonstrated methods to...Ch. 18 - Nonhomologous end-joining NHEJ of a double-strand...Ch. 18 - One problem that researchers sometimes encounter...Ch. 18 - Researchers at the University of California at San...Ch. 18 - Prob. 28PCh. 18 - F. Port and S. Bullock at the University of...Ch. 18 - On Fig 18.14, locate the PAM site and identify the...Ch. 18 - Prob. 31PCh. 18 - Prob. 32PCh. 18 - Recall that Leber congenital amaurosis LCA, a form...Ch. 18 - One potential strategy for gene therapy to correct...Ch. 18 - Recently, scientists have used a mouse model for...
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