Molecular Cell Biology
Molecular Cell Biology
8th Edition
ISBN: 9781464183393
Author: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Kelsey C. Martin
Publisher: W. H. Freeman
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Chapter 18, Problem 1RTC
Summary Introduction

To determine:

The reason behind the polarity of the microtubules, how they are organized within the cell and to explain how their polarity is related to the intracellular movements powered by microtubule-dependent motors.

Introduction:

The function of the microtubules is to give support, shape to the cell, participate in motor functions and transport organelles. Microtubules are polar filaments of the cells; they have different polarity on both the ends. One end is the plus one which grows fast and the other end is the minus one which grows slow.

Expert Solution & Answer
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Explanation of Solution

The reason for the polarity of the microtubules is explained below:

The arrangement of the tubulin proteins in the microtubules defines their polarity.Tubulin protein is of two types- alpha-tubulin and beta-tubulin. Alpha-tubulin goes to the (+) end and beta-tubulin goes to the (−) end of the microtubules.

The way microtubules are organized in a cell also depends on their polarity- the (+) end lies on the outer side and the(−) end lies towards the inner side of the cell. There are Microtubules Organizing Centers inside the cell which helps in the arrangement of microtubules.

There are two microtubule-bound proteins which help in their intracellular movement − Kinesin and Dynein. Kinesis helps in moving them towards the (+) end and Dynein helps in moving towards the (-) end, thus facilitating their intracellular movement.

Conclusion

The arrangement of the tubulin proteins in the microtubules defines their polarity. Alpha-tubulin goes to the (+) end and beta-tubulin goes to the (−) end of the microtubules.

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