Chapter 18, Problem 1P

(a)

Summary Introduction

To draw and name: The structure of α-keto acid which results from the transamination reaction of α-ketoglutarate with aspartate.

Introduction:

The α-amino acid is transferred to the a-carbon atom of α-ketoglutarate and leaves behind the corresponding α-keto acid is known as transamination reaction. This transfer of amino group is through the enzymes known as transferases or transaminases. 

Answer to Problem 1P

Correct answer: Fig.1: Structure of oxaloacetate.

Fig.1: Structure of oxaloacetate.

Explanation of Solution

Explanation:

The structure of α-keto acid which results from the reaction of amino acids with α-ketoglutarate is as follow:

$\text{α-}\text{ketoglutrate}+\text{aspartate}\to \text{oxaloacetate}$

The final product obtained from the reaction is oxaloacetate.

(b)

Summary Introduction

To draw and name: The structure of α-keto acid which results from the transamination reaction of α-ketoglutarate with glutamate.

Introduction:

The α-amino acid is transferred to the a-carbon atom of α-ketoglutarate and leaves behind the corresponding α-keto acidis known as transamination reaction. This transfer of amino group is through the enzymes known as transferases or transaminases.

Answer to Problem 1P

Correct answer: Fig.1: Structure of α-ketoglutarate.

Fig.1: Structure of α-ketoglutarate.

Explanation of Solution

Explanation:

The structure of α-keto acid which results from the reaction of amino acids with α-ketoglutarate is as follow:

$\text{α-ketoglutarate}+\text{glutamate}\to \text{α-ketoglutarate}$

The α-ketoglutarate is the final product obtained from the reaction.

(c)

Summary Introduction

To draw and name: The structure of α-keto acid which results from the transamination reaction of α-ketoglutarate with alanine.

Introduction:

The α-amino acid is transferred to the a-carbon atom of α-ketoglutarate and leaves behind the corresponding α-keto acid is known as transamination reaction. This transfer of amino group is through the enzymes known as transferases or transaminases. 

Answer to Problem 1P

Correct answer: Fig.1: Structure of pyruvate.

Fig.1: Structure of pyruvate.

Explanation of Solution

Explanation:

The structure of α-keto acid which results from the reaction of amino acids with α-ketoglutarate is as follow:

$\text{α-ketoglutarate}+\text{alanine}\to \text{pyruvate}$

Pyruvate is the final product obtained from the reaction.

(d)

Summary Introduction

To draw and name: The structure of α-keto acid which results from the transamination reaction of α-ketoglutarate with phenylalnine.

Introduction:

The α-amino acid is transferred to the a-carbon atom of α-ketoglutarate and leaves behind the corresponding α-keto acid is known as transamination reaction. This transfer of amino group is through the enzymes known as transferases or transaminases.

Answer to Problem 1P

Correct answer: Fig.1: Structure of phenylpyruvate.

Fig.1: Structure of phenylpyruvate.

Explanation of Solution

Explanation:

The structure of α-keto acid which results from the reaction of amino acids with α-ketoglutarate is as follow:

$\text{α-ketoglutarate}+\text{phenylalanine}\to \text{phenylpyruvate}$

phenylpyruvate is the final product obtained from the reaction.