Why do you think it has been so difficult to identify genes underlying schizophrenia? Rachel asked to see a genetic counselor because she was concerned about developing schizophrenia. Her mother and maternal grandmother both had schizophrenia and were institutionalized for most of their adult lives. Rachel’s three maternal aunts are all in their 60s and have not shown any signs of this disease. Rachel’s father is alive and healthy, and his family history does not suggest any behavioral or genetic conditions. The genetic counselor discussed the multifactorial nature of schizophrenia and explained that many candidate genes have been identified that may be mutated in individuals with the condition. However, a genetic test is not available for presymptomatic testing. The counselor explained that based on Rachel’s family history and her relatedness to individuals who have schizophrenia, her risk of developing it is approximately 13%. If an altered gene is in the family and her mother carries the gene, Rachel has a 50% chance of inheriting it.

Question

Want to see more full solutions like this?

Answer 1

Textbook Question

Chapter 18, Problem 1CS

Why do you think it has been so difficult to identify genes underlying schizophrenia?

Rachel asked to see a genetic counselor because she was concerned about developing schizophrenia. Her mother and maternal grandmother both had schizophrenia and were institutionalized for most of their adult lives. Rachel’s three maternal aunts are all in their 60s and have not shown any signs of this disease. Rachel’s father is alive and healthy, and his family history does not suggest any behavioral or genetic conditions. The genetic counselor discussed the multifactorial nature of schizophrenia and explained that many candidate genes have been identified that may be mutated in individuals with the condition. However, a genetic test is not available for presymptomatic testing. The counselor explained that based on Rachel’s family history and her relatedness to individuals who have schizophrenia, her risk of developing it is approximately 13%. If an altered gene is in the family and her mother carries the gene, Rachel has a 50% chance of inheriting it.

Expert Solution & Answer

Summary Introduction

To describe: The difficulties to identify genes underlying schizophrenia.

Introduction: Schizophrenia is characterized by thought disorders, delusions, and anti-social behavior. This is much common in children and at least lasts for 6 months. Schizophrenia is found within a region of DNA located on chromosome 6. The genes underlying the disease are still unknown.

Explanation of Solution

Schizophrenia is a behavioral disorder that causes widespread human suffering. Several genetic studies have shown that hundreds of genes are linked to schizophrenia. Each gene contributes a small part to the risk of developing the disease.

Therefore, a mutation in a gene does not confirm the presence of schizophrenia. Similarly, if someone has schizophrenia with a mutation in a gene also does not mean that this mutation is responsible for the behavior of the respective person.

Hence, it is difficult to find genetic determinants underlying schizophrenia.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Students have asked these similar questions

When using the concept of "a calorie in is equal to a calorie out" how important is the quality of the calories?

What did the Cre-lox system used in the Kikuchi et al. 2010 heart regeneration experiment allow researchers to investigate? What was the purpose of the cmlc2 promoter? What is CreER and why was it used in this experiment? If constitutively active Cre was driven by the cmlc2 promoter, rather than an inducible CreER system, what color would you expect new cardiomyocytes in the regenerated area to be no matter what? Why?

What kind of organ size regulation is occurring when you graft multiple organs into a mouse and the graft weight stays the same?

Answer 2

Textbook Question

Chapter 18, Problem 1CS

Why do you think it has been so difficult to identify genes underlying schizophrenia?

Rachel asked to see a genetic counselor because she was concerned about developing schizophrenia. Her mother and maternal grandmother both had schizophrenia and were institutionalized for most of their adult lives. Rachel’s three maternal aunts are all in their 60s and have not shown any signs of this disease. Rachel’s father is alive and healthy, and his family history does not suggest any behavioral or genetic conditions. The genetic counselor discussed the multifactorial nature of schizophrenia and explained that many candidate genes have been identified that may be mutated in individuals with the condition. However, a genetic test is not available for presymptomatic testing. The counselor explained that based on Rachel’s family history and her relatedness to individuals who have schizophrenia, her risk of developing it is approximately 13%. If an altered gene is in the family and her mother carries the gene, Rachel has a 50% chance of inheriting it.

Expert Solution & Answer

Summary Introduction

To describe: The difficulties to identify genes underlying schizophrenia.

Introduction: Schizophrenia is characterized by thought disorders, delusions, and anti-social behavior. This is much common in children and at least lasts for 6 months. Schizophrenia is found within a region of DNA located on chromosome 6. The genes underlying the disease are still unknown.

Explanation of Solution

Schizophrenia is a behavioral disorder that causes widespread human suffering. Several genetic studies have shown that hundreds of genes are linked to schizophrenia. Each gene contributes a small part to the risk of developing the disease.

Therefore, a mutation in a gene does not confirm the presence of schizophrenia. Similarly, if someone has schizophrenia with a mutation in a gene also does not mean that this mutation is responsible for the behavior of the respective person.

Hence, it is difficult to find genetic determinants underlying schizophrenia.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 3

Textbook Question

Chapter 18, Problem 1CS

Why do you think it has been so difficult to identify genes underlying schizophrenia?

Rachel asked to see a genetic counselor because she was concerned about developing schizophrenia. Her mother and maternal grandmother both had schizophrenia and were institutionalized for most of their adult lives. Rachel’s three maternal aunts are all in their 60s and have not shown any signs of this disease. Rachel’s father is alive and healthy, and his family history does not suggest any behavioral or genetic conditions. The genetic counselor discussed the multifactorial nature of schizophrenia and explained that many candidate genes have been identified that may be mutated in individuals with the condition. However, a genetic test is not available for presymptomatic testing. The counselor explained that based on Rachel’s family history and her relatedness to individuals who have schizophrenia, her risk of developing it is approximately 13%. If an altered gene is in the family and her mother carries the gene, Rachel has a 50% chance of inheriting it.

Expert Solution & Answer

Summary Introduction

To describe: The difficulties to identify genes underlying schizophrenia.

Introduction: Schizophrenia is characterized by thought disorders, delusions, and anti-social behavior. This is much common in children and at least lasts for 6 months. Schizophrenia is found within a region of DNA located on chromosome 6. The genes underlying the disease are still unknown.

Explanation of Solution

Schizophrenia is a behavioral disorder that causes widespread human suffering. Several genetic studies have shown that hundreds of genes are linked to schizophrenia. Each gene contributes a small part to the risk of developing the disease.

Therefore, a mutation in a gene does not confirm the presence of schizophrenia. Similarly, if someone has schizophrenia with a mutation in a gene also does not mean that this mutation is responsible for the behavior of the respective person.

Hence, it is difficult to find genetic determinants underlying schizophrenia.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 4

Textbook Question

Chapter 18, Problem 1CS

Why do you think it has been so difficult to identify genes underlying schizophrenia?

Rachel asked to see a genetic counselor because she was concerned about developing schizophrenia. Her mother and maternal grandmother both had schizophrenia and were institutionalized for most of their adult lives. Rachel’s three maternal aunts are all in their 60s and have not shown any signs of this disease. Rachel’s father is alive and healthy, and his family history does not suggest any behavioral or genetic conditions. The genetic counselor discussed the multifactorial nature of schizophrenia and explained that many candidate genes have been identified that may be mutated in individuals with the condition. However, a genetic test is not available for presymptomatic testing. The counselor explained that based on Rachel’s family history and her relatedness to individuals who have schizophrenia, her risk of developing it is approximately 13%. If an altered gene is in the family and her mother carries the gene, Rachel has a 50% chance of inheriting it.

Expert Solution & Answer

Summary Introduction

To describe: The difficulties to identify genes underlying schizophrenia.

Introduction: Schizophrenia is characterized by thought disorders, delusions, and anti-social behavior. This is much common in children and at least lasts for 6 months. Schizophrenia is found within a region of DNA located on chromosome 6. The genes underlying the disease are still unknown.

Explanation of Solution

Schizophrenia is a behavioral disorder that causes widespread human suffering. Several genetic studies have shown that hundreds of genes are linked to schizophrenia. Each gene contributes a small part to the risk of developing the disease.

Therefore, a mutation in a gene does not confirm the presence of schizophrenia. Similarly, if someone has schizophrenia with a mutation in a gene also does not mean that this mutation is responsible for the behavior of the respective person.

Hence, it is difficult to find genetic determinants underlying schizophrenia.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 5

Textbook Question

Answer 6

Textbook Question

Answer 7

Expert Solution & Answer

Summary Introduction

To describe: The difficulties to identify genes underlying schizophrenia.

Introduction: Schizophrenia is characterized by thought disorders, delusions, and anti-social behavior. This is much common in children and at least lasts for 6 months. Schizophrenia is found within a region of DNA located on chromosome 6. The genes underlying the disease are still unknown.

Explanation of Solution

Schizophrenia is a behavioral disorder that causes widespread human suffering. Several genetic studies have shown that hundreds of genes are linked to schizophrenia. Each gene contributes a small part to the risk of developing the disease.

Therefore, a mutation in a gene does not confirm the presence of schizophrenia. Similarly, if someone has schizophrenia with a mutation in a gene also does not mean that this mutation is responsible for the behavior of the respective person.

Hence, it is difficult to find genetic determinants underlying schizophrenia.

Answer 8

Expert Solution & Answer

Summary Introduction

To describe: The difficulties to identify genes underlying schizophrenia.

Introduction: Schizophrenia is characterized by thought disorders, delusions, and anti-social behavior. This is much common in children and at least lasts for 6 months. Schizophrenia is found within a region of DNA located on chromosome 6. The genes underlying the disease are still unknown.

Explanation of Solution

Schizophrenia is a behavioral disorder that causes widespread human suffering. Several genetic studies have shown that hundreds of genes are linked to schizophrenia. Each gene contributes a small part to the risk of developing the disease.

Therefore, a mutation in a gene does not confirm the presence of schizophrenia. Similarly, if someone has schizophrenia with a mutation in a gene also does not mean that this mutation is responsible for the behavior of the respective person.

Hence, it is difficult to find genetic determinants underlying schizophrenia.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Summary Introduction

To describe: The difficulties to identify genes underlying schizophrenia.

Introduction: Schizophrenia is characterized by thought disorders, delusions, and anti-social behavior. This is much common in children and at least lasts for 6 months. Schizophrenia is found within a region of DNA located on chromosome 6. The genes underlying the disease are still unknown.

Answer 12

Explanation of Solution

Schizophrenia is a behavioral disorder that causes widespread human suffering. Several genetic studies have shown that hundreds of genes are linked to schizophrenia. Each gene contributes a small part to the risk of developing the disease.

Therefore, a mutation in a gene does not confirm the presence of schizophrenia. Similarly, if someone has schizophrenia with a mutation in a gene also does not mean that this mutation is responsible for the behavior of the respective person.

Hence, it is difficult to find genetic determinants underlying schizophrenia.

Answer 13

Ch. 18.2 - What role would twin and adoption studies play in...Ch. 18.2 - Prob. 2EG Ch. 18 - Why do you think it has been so difficult to...Ch. 18 - If a test were available that could tell you...Ch. 18 - Prob. 1QP Ch. 18 - Prob. 2QP Ch. 18 - Prob. 3QP Ch. 18 - List the steps involved in transmitting a nerve...Ch. 18 - Why do neurotransmitters have to be removed from...Ch. 18 - Prob. 6QP

Concept explainers

Videos

Explanation of Solution

Want to see more full solutions like this?

Chapter 18 Solutions