The way by which tolazamide is synthesized has to be shown. Concept introduction: Reaction of an ester with ammonia or an amine : Treatment of an ester with ammonia or a primary or secondary amine gives an amide. The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Question

Want to see the full answer?

Answer 1

Question

Chapter 18, Problem 18.46P

(a)

Interpretation Introduction

Interpretation:

The way by which tolazamide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

(b)

Interpretation Introduction

Interpretation:

The way by which Gliclazide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

From the following potentials, calculate the activity of Cl- in saturated KCl. E0 (calomel electrode)= 0.268 V E (calomel electrode, saturated KCl)= 0.241 V

Calculate the voltage of each of the following cells. a) Fe(s)/Fe2+ (1.55 x 10-2 M)//Cu2+ (6.55 x 10-3 M)/Cu(s) b) Pt, H2 (0.255 bar)/HCl (4.55 x 10-4 M), AgCl (sat'd)/Ag Fe2+ +2e- = Fe E0= -0.44 V Cu2+ + 2e- = Cu E0= 0.337 V Ag+ + e- = Ag E0= 0.799 V AgCl(s) + e- = Ag(s) + Cl- E0= 0.222 V 2H+ + 2e- = H2 E0= 0.000 V

A solution contains 0.097 M Ce3+, 1.55x10-3 M Ce4+, 1.55x10-3 M Mn2+, 0.097 M MnO4-, and 1.00 M HClO4 (F= 9.649 x 104 C/mol). a) Write a balanced net reaction that can occur between species in this solution. b) Calculate deltaG0 and K for the reaction. c) Calculate E and deltaG for the conditions given. Ce4+ + e- = Ce3+ E0= 1.70 V MnO4- + 8H+ + 5e- = Mn2+ + 4H2O E0= 1.507 V

Answer 2

Question

Chapter 18, Problem 18.46P

(a)

Interpretation Introduction

Interpretation:

The way by which tolazamide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

(b)

Interpretation Introduction

Interpretation:

The way by which Gliclazide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 18, Problem 18.46P

(a)

Interpretation Introduction

Interpretation:

The way by which tolazamide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

(b)

Interpretation Introduction

Interpretation:

The way by which Gliclazide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 18, Problem 18.46P

(a)

Interpretation Introduction

Interpretation:

The way by which tolazamide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

(b)

Interpretation Introduction

Interpretation:

The way by which Gliclazide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 18, Problem 18.46P

(a)

Interpretation Introduction

Interpretation:

The way by which tolazamide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

(b)

Interpretation Introduction

Interpretation:

The way by which Gliclazide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Answer 6

Chapter 18, Problem 18.46P

(a)

Interpretation Introduction

Interpretation:

The way by which tolazamide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Answer 7

Chapter 18, Problem 18.46P

(a)

Interpretation Introduction

Interpretation:

The way by which tolazamide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Answer 8

(b)

Interpretation Introduction

Interpretation:

The way by which Gliclazide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Answer 9

(b)

Interpretation Introduction

Interpretation:

The way by which Gliclazide is synthesized has to be shown.

Concept introduction:

Reaction of an ester with ammonia or an amine:

Treatment of an ester with ammonia or a primary or secondary amine gives an amide.

The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.

Answer 10

Expert Solution & Answer

Answer 11

Expert Solution & Answer

Answer 12

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 13

Ch. 18.1 - Prob. 18.1P Ch. 18.2 - Prob. 18.2P Ch. 18.4 - Prob. 18.3P Ch. 18.4 - Prob. 18.4P Ch. 18.4 - Synthesis of nitriles by nucleophilic displacement...Ch. 18.5 - Complete the following transesterification...Ch. 18.6 - Complete and balance equations for the following...Ch. 18.8 - Prob. AQ Ch. 18.8 - Several compounds have been found to inhibit...Ch. 18.8 - Prob. CQ

Solution Summary: The author explains how tolazamide is synthesized by converting an amine to a carbamic ester.

Want to see the full answer?

Chapter 18 Solutions