Becker's World of the Cell (9th Edition)
Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 18, Problem 18.1CC

Suppose a triplet on the template strand of a piece of DNA has the sequence 5′-ATA-3′. What would be the consequences if the sequence were mutated to GTA? TTA? GCA? Explain your answer in each case.

Expert Solution
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Summary Introduction

To determine: The consequences if a sequence 5ʹ-ATA-3ʹ on template strand of DNA has been mutated to GTA.

Introduction: The specific sequences which are present on template strand of DNA (Deoxyribose nucleic acid) in the form of triplet codons will transmit the information for the formation of messenger RNA (Ribose nucleic acid) and proteins.

Explanation of Solution

When a sequence of 5ʹ-ATA-3ʹ on template strand of DNA has been mutated to GTA, it will lead to the formation of messenger RNA having triplet codons UAC in 3' to 5' direction. It occurs because if ATA was present, the resulting messenger RNA would be UAU. Therefore, due to the mutation, UAC will code for amino acid tyrosine similar to UAU because of both UAU and UAC code for amino acid tyrosine.

(b)

Expert Solution
Check Mark
Summary Introduction

To determine: The consequences if a sequence 5ʹ-ATA-3ʹ on template strand of DNA has been mutated to TTA.

Introduction: The specific sequences which are present on template strand of DNA (Deoxyribose nucleic acid) in the form of triplet codons will transmit the information for the formation of messenger RNA (Ribose nucleic acid) and proteins.

Explanation of Solution

When a sequence of 5ʹ-ATA-3ʹ on template strand of DNA has been mutated to TTA, it will lead to the formation of messenger RNA having triplet codons UAA in 3' to 5' direction. It occurs because if ATA was present, the resulting messenger RNA would be UAU. Therefore, due to the mutation, UAA will code for stop codon instead of tyrosine that would be coded by UAU.

(c)

Expert Solution
Check Mark
Summary Introduction

To determine: The consequences if a sequence 5ʹ-ATA-3ʹ on template strand of DNA has been mutated to GCA.

Introduction: The specific sequences which are present on template strand of DNA (Deoxyribose nucleic acid) in the form of triplet codons will transmit the information for the formation of messenger RNA (Ribose nucleic acid) and proteins.

Explanation of Solution

When a sequence of 5ʹ-ATA-3ʹ on template strand of DNA has been mutated to GCA, it will lead to the formation of messenger RNA having triplet codons UGC in 3' to 5' direction. It occurs because if ATA was present, the resulting messenger RNA would be UAU. Therefore, due to the mutation, UGC will code for amino acid cysteine instead of tyrosine that would be coded by UAU.

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