FUNDAMENTALS OF BIOCHEMISTRY WPNG 1-SEME
5th Edition
ISBN: 9781119750192
Author: Voet
Publisher: WILEY
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Chapter 18, Problem 11E
Summary Introduction
To explain: The intermolecular forces involved in the association of cardiolipin and cytochrome c.
Concept introduction: Cardiolipin is a phospholipid that is present as a part of lipid bilayer of cells and cell organelles. Cytochrome c is the electron carrier in the electron transport chain between the complex III and complex IV.
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Compare and contrast the structural features of the ion carrier valinomycin with those of achannel former like gramicidin. How does structural information help explain the mechanismby which these molecules conduct ions across membranes?
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The titration curve of alanine shows the ionization of two functional groups with pK values of 2.34 and 9.69, corresponding to
the ionization of the carboxyl and the protonated amino groups, respectively. The titration of di-, tri-, and larger oligopeptides of
alanine also shows the ionization of only two functional groups, although the experimental pK values are different. The table
summarizes the trend in pK values.
Amino acid or peptide
Ala
Ala-Ala
pKj
pk₂
2.34
9.69
3.12
8.30
Ala-Ala-Ala
3.39
8.03
Ala-(Ala)-Ala, n ≥ 4
3.42
7.94
Modify the molecules to show the oligopeptide Ala-Ala-Ala. You can modify the molecules by moving, adding,
deleting, or changing atoms, bonds, or charges.
C
Select
c
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Templates
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H с N 0
S
Cl
H
H
| | ||
H CH3
H
CH,
H CH₂
Complete the statements about the the pK, values of the Ala-Ala-Ala oligopeptide.
The pK₁ value of 3.39 is associated with the
-COO group of Ala-Ala-Ala.
The pK2 value of 8.03 is associated with the -NH
group of Ala-Ala-Ala.
Erase
Q2 Q…
Chapter 18 Solutions
FUNDAMENTALS OF BIOCHEMISTRY WPNG 1-SEME
Ch. 18 - Prob. 1ECh. 18 - 2. Certain genetic diseases caused by defective...Ch. 18 - 3. How many ATPs are synthesized for every...Ch. 18 - 4. How many ATPs are synthesized for every...Ch. 18 - 5. Explain why defects in mitochondrial genes...Ch. 18 - 6. Deficiencies of the components of Complexes I,...Ch. 18 - 7. Calculate ?G°+ for the oxidation of free FADH2...Ch. 18 - 8. Show that the free energy change for the...Ch. 18 - Prob. 9ECh. 18 - Prob. 10E
Ch. 18 - Prob. 11ECh. 18 - 12. Under certain conditions, cytochrome c can...Ch. 18 - 13. Some anaerobic prokaryotes use nitrate (NO3?)...Ch. 18 - 14. Some anaerobic prokaryotes reduce elemental...Ch. 18 - Prob. 15ECh. 18 - Prob. 16ECh. 18 - 17. Bombarding a suspension of mitochondria with...Ch. 18 - 18. For the experimental system described in...Ch. 18 - 19. Consider the mitochondrial ADP-ATP...Ch. 18 - 20. What thermodynamic force drives the transport...Ch. 18 - Prob. 21ECh. 18 - Prob. 22ECh. 18 - 23. Explain why compounds such as DNP increase...Ch. 18 - 24. What is the advantage of hormones activating a...Ch. 18 - 25. Describe the changes in [NADH]/[NAD+] and...Ch. 18 - 26. During cell signaling events that increase...Ch. 18 - 27. Activated neutrophils and macrophages (types...Ch. 18 - 28. Mutations in SOD arc associated with the...Ch. 18 - Prob. 29CQCh. 18 - 30. Sketch the O2-consuntption curves obtained for...Ch. 18 - Prob. 31CQCh. 18 - 32. For the mitochondrial membrane described in...Ch. 18 - 33. Nicotinamide nucleotide transhydrogenase (NNT)...Ch. 18 - 34. The antidiabetes drug metformin inhibits...Ch. 18 - 35. How do the P/O ratios for NADH differ in ATP...Ch. 18 - 36. How many protons are required to synthesize...Ch. 18 - 37. During dietary restriction, amino acids may be...Ch. 18 - Prob. 38CQCh. 18 - 39. In coastal marine environments, high...Ch. 18 - Prob. 40CQCh. 18 - 41. (a) A simplistic interpretation of the Q cycle...Ch. 18 - Prob. 42CQCh. 18 - MORE TO EXPLORE Anaerobic organisms produce ATP by...
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