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a)
Interpretation:
Synthesis of ketoprofen from the given starting material is to be stated.
Concept Introduction:
The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is
b)
Interpretation:
The reasons corresponding to the different synthesis processes for both the ketoprofen and ibuprofen irrespective of common propionic acid sub unit is to be stated.
Concept Introduction:
The compound ketoprofen is an anti-inflammatory drug with antipyretic and analgesic effect. The chemical name of this compound is
Ibuprofen is the non-steroidal and anti-inflammatory drug. It is used to treat pain, fever and inflammation.
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Chapter 18 Solutions
Organic Chemistry (8th Edition)
- ripelennamine is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; hay fever; urticaria; and rhinitis. Based on biotransformations discussed in class, draw the structures of 3 possible metabolites of tripelennamine.arrow_forwardDefine Enamine Formation from an Aldehyde or a Ketone ?arrow_forward1. Why is acetanilide no longer available as a drug in the market? 2. Why is the synthesis of acetanilide still relevant? 3. Can acetanilide be re-offered to market again?arrow_forward
- Show how to convert 4-methoxybenzyl chloride to each amine.arrow_forwardTwo reactions occur when sodium hydroxide is added to methyl salicylate. One is immediate and one only occurs with reflux over time. What type of reaction occurs immediately and with which functional group on methyl salicylate does it react? What type of reaction occurs with reflux over time and with which functional group on methyl salicylate does it react?arrow_forwardchoose from the following compoundsarrow_forward
- Why is there a need to add two (2) equivalents of amine in the reaction of an acid chloride and an amine ? A) The extra amine will deprotonate the amine or alcohol, making it a better nucleophile. B) The extra amine will neutralize the acid by-product of the reaction. C) The extra amine will protonate the carbonyl of the acid chloride, making it more reactive. D) The extra amine will absorb the heat of the reaction.arrow_forwardDraw the products formed when each amine is treated with [1] CH3I (excess); [2] Ag2O; [3] Δ. Indicate the major product when a mixture results.arrow_forwardAlthough γ-butyrolactone is a biologically inactive compound, it isconverted in the body to 4-hydroxybutanoic acid (GHB), an addictive andintoxicating recreational drug. Draw a stepwise mechanism for thisconversion in the presence of acid.arrow_forward
- Why is it not advisable to use aqueous hydrochloric acid in a Grignard reaction of a ketone? A) The Grignard reagent will react with the acid and cannot react with the ketone. B) The ketone will be protonated and will become unreactive. C) The ketone will form an unreactive enol. D) The Grignard reagent won't dissolve in aqueous solutionsarrow_forwardWhat products are formed when all of the amide and ester bonds are hydrolyzed in each of the following compounds? Tamiflu [part (a)] is the trade name of the antiviral agent oseltamivir, thought to be the most effective agent in treating influenza. Aspartame [part (b)] is the artificial sweetener used in Equal and many diet beverages. One of the products of this hydrolysis reaction is the amino acid phenylalanine. Infants afflicted with phenylketonuria cannot metabolize this amino acid, so it accumulates, causing mental retardation. When the affliction is identified early, a diet limiting the consumption of phenylalanine (and compounds like aspartame that are converted to it) can make a normal life possible.arrow_forwardWhy is methyl salicylate so easily absorbed through the skin?arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage LearningOrganic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage LearningChemistry for Today: General, Organic, and Bioche...ChemistryISBN:9781305960060Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. HansenPublisher:Cengage Learning
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