The following given compounds prepared from cyclohexanone using an enamine intermediate. 2-propylcyclohexanone Concept introduction: To increase the carbon chain, substituting an alkyl group on alpha carbon of a carbonyl group is called alkylation. Alkylation is carried out by reaction of a ketone with a secondary amine in the presence of an acid to form an enamine and then adding an appropriate alkyl halide . The alkylation is a S N 2 reaction. The alkylation works best with a primary alkyl halide. Acylation is carried out by reaction of a ketone with a secondary amine in the presence of an acid to form an enamine and then adding an appropriate acyl halide. The acylation is an addition reaction.

Question

Predict the major products of the following organic reaction: Some important notes: Δ CN ? • Draw the major product, or products, of the reaction in the drawing area below. • If there aren't any products, because no reaction will take place, check the box below the drawing area instead. Be sure to use wedge and dash bonds when necessary, for example to distinguish between major products that are enantiomers. ONO reaction. Click and drag to start drawing a structure.

Answer 1

Question

Chapter 17.8, Problem 17P

(a)

Interpretation Introduction

Interpretation: The following given compounds prepared from cyclohexanone using an enamine intermediate.

$2-propylcyclohexanone$

Concept introduction: To increase the carbon chain, substituting an alkyl group on alpha carbon of a carbonyl group is called alkylation.

Alkylation is carried out by reaction of a ketone with a secondary amine in the presence of an acid to form an enamine and then adding an appropriate alkyl halide. The alkylation is a $SN2$ reaction. The alkylation works best with a primary alkyl halide.

Acylation is carried out by reaction of a ketone with a secondary amine in the presence of an acid to form an enamine and then adding an appropriate acyl halide. The acylation is an addition reaction.

(b)

Interpretation Introduction

Interpretation: The given compounds prepared from cyclohexanone using an enamine intermediate.

$2-propanoncyclohex-1-one$

Concept introduction: To increase the carbon chain, substituting an alkyl group on alpha carbon of a carbonyl group is called alkylation.

Alkylation is carried out by reaction of a ketone with a secondary amine in the presence of an acid to form an enamine and then adding an appropriate alkyl halide. The alkylation is a $SN2$ reaction. The alkylation works best with a primary alkyl halide.

Acylation is carried out by reaction of a ketone with a secondary amine in the presence of an acid to form an enamine and then adding an appropriate acyl halide. The acylation is an addition reaction.

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