The mechanism of the given mannich reaction has to be proposed. Concept introduction: The mannich reaction is an organic reaction which consists of amino alkylation of an acidic proton placed next to a carbonyl functional group by formaldehyde and a primary or a secondary amine or ammonia. The final product is a β-aminocarbonyl compound. The mannich reaction is an example of nucleophilic addition of an amine to carbonyl group followed by dehydration to the Schiff base.

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Chapter 17, Problem 78P

Interpretation Introduction

Interpretation:

The mechanism of the given mannich reaction has to be proposed.

Concept introduction:

The mannich reaction is an organic reaction which consists of amino alkylation of an acidic proton placed next to a carbonyl functional group by formaldehyde and a primary or a secondary amine or ammonia. The final product is a β-aminocarbonyl compound.

The mannich reaction is an example of nucleophilic addition of an amine to carbonyl group followed by dehydration to the Schiff base.

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