Genetics: A Conceptual Approach
6th Edition
ISBN: 9781319050962
Author: Benjamin A. Pierce
Publisher: W. H. Freeman
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Chapter 17.3, Problem 3TPSQ
Summary Introduction
To determine:
The overall effect of decreasing the amount of mediator present in a cell.
Introduction:
Transcription is a very significant level of gene expression control in eukaryotes and needs various types of regulatory elements and proteins. Transcription factors which are important for the process of transcription consist of basal transcription apparatus. Basal transcription apparatus is a complex of regulatory proteins, transcription factors and RNA polymerase.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 17 Solutions
Genetics: A Conceptual Approach
Ch. 17.1 - Prob. 2COQCh. 17.2 - Prob. 1CCCh. 17.2 - Prob. 3COQCh. 17.2 - Prob. 4COQCh. 17.2 - Prob. 5COQCh. 17.2 - Prob. 6COQCh. 17.2 - Prob. 15AQPCh. 17.2 - Prob. 16AQPCh. 17.2 - Prob. 17AQPCh. 17.2 - Prob. 18AQP
Ch. 17.2 - Prob. 19AQPCh. 17.2 - Prob. 1TPSQCh. 17.2 - Prob. 2TPSQCh. 17.3 - Prob. 2CCCh. 17.3 - Prob. 3CCCh. 17.3 - Prob. 7COQCh. 17.3 - Prob. 8COQCh. 17.3 - Prob. 9COQCh. 17.3 - Prob. 10COQCh. 17.3 - Prob. 20AQPCh. 17.3 - Prob. 21AQPCh. 17.3 - Prob. 22AQPCh. 17.3 - Prob. 23AQPCh. 17.3 - Prob. 29CQCh. 17.3 - Prob. 3TPSQCh. 17.3 - Prob. 4TPSQCh. 17.3 - Prob. 5TPSQCh. 17.4 - Prob. 4CCCh. 17.4 - Prob. 11COQCh. 17.4 - Prob. 12COQCh. 17.4 - Prob. 24AQPCh. 17.4 - Prob. 25AQPCh. 17.4 - Prob. 26AQPCh. 17.4 - Prob. 27AQPCh. 17.4 - Prob. 6TPSQCh. 17.5 - Prob. 5CCCh. 17.5 - Prob. 13COQCh. 17.5 - Prob. 28AQPCh. 17.5 - Prob. 30CQCh. 17.6 - Prob. 14COQCh. 17.6 - Prob. 7TPSQCh. 17.6 - Prob. 8TPSQCh. 17 - Prob. 1COQ
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