Human Anatomy
5th Edition
ISBN: 9780073403700
Author: Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Chapter 17.3, Problem 13BYGO
How does the brain recognize the difference between high C and middle C of a piano? Between a loud sound and a soft one?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 17 Solutions
Human Anatomy
Ch. 17.1 - Prob. 1AWYKCh. 17.1 - Distinguish between general and special senses.Ch. 17.1 - Three schemes of receptor classification were...Ch. 17.1 - Prob. 3BYGOCh. 17.1 - Prob. 4BYGOCh. 17.1 - Prob. 5BYGOCh. 17.1 - Prob. 6BYGOCh. 17.2 - Prob. 1AWYKCh. 17.2 - What is the difference between a lingual papilla...Ch. 17.2 - Prob. 8BYGO
Ch. 17.2 - What part of an olfactory cell bears the binding...Ch. 17.2 - Prob. 10BYGOCh. 17.3 - Prob. 1AWYKCh. 17.3 - What is the benefit of having three auditory...Ch. 17.3 - Prob. 12BYGOCh. 17.3 - How does the brain recognize the difference...Ch. 17.3 - Prob. 14BYGOCh. 17.3 - Prob. 15BYGOCh. 17.4 - Prob. 1AWYKCh. 17.4 - Prob. 2AWYKCh. 17.4 - Prob. 3AWYKCh. 17.4 - Prob. 16BYGOCh. 17.4 - List as many structural and functional differences...Ch. 17.4 - Prob. 18BYGOCh. 17.4 - Prob. 19BYGOCh. 17.5 - Describe the contributions of the first pharyngeal...Ch. 17.5 - Prob. 21BYGOCh. 17.5 - Prob. 22BYGOCh. 17.5 - Prob. 23BYGOCh. 17 - The meaning of sensory receptor and the range of...Ch. 17 - Prob. 17.1.2AYLOCh. 17 - Prob. 17.1.3AYLOCh. 17 - Prob. 17.1.4AYLOCh. 17 - Prob. 17.1.5AYLOCh. 17 - The types of sensory nerve endings considered to...Ch. 17 - Prob. 17.1.7AYLOCh. 17 - Prob. 17.1.8AYLOCh. 17 - Prob. 17.1.9AYLOCh. 17 - Prob. 17.1.10AYLOCh. 17 - Prob. 17.1.11AYLOCh. 17 - Prob. 17.1.12AYLOCh. 17 - Prob. 17.1.13AYLOCh. 17 - The relationship of taste buds to the lingual...Ch. 17 - Prob. 17.2.2AYLOCh. 17 - Prob. 17.2.3AYLOCh. 17 - Prob. 17.2.4AYLOCh. 17 - Prob. 17.2.5AYLOCh. 17 - Prob. 17.2.6AYLOCh. 17 - Prob. 17.2.7AYLOCh. 17 - Prob. 17.3.1AYLOCh. 17 - Prob. 17.3.2AYLOCh. 17 - The parts of the middle ear, including its three...Ch. 17 - Prob. 17.3.4AYLOCh. 17 - The anatomy of the cochlea and the functional...Ch. 17 - Prob. 17.3.6AYLOCh. 17 - How cochlear function enables the brain to...Ch. 17 - Prob. 17.3.8AYLOCh. 17 - The differences between static and dynamic...Ch. 17 - Prob. 17.3.10AYLOCh. 17 - The action of the otolithic membrane in...Ch. 17 - Prob. 17.3.12AYLOCh. 17 - Prob. 17.3.13AYLOCh. 17 - The projection pathways taken by signals of...Ch. 17 - Prob. 17.4.1AYLOCh. 17 - Prob. 17.4.2AYLOCh. 17 - Prob. 17.4.3AYLOCh. 17 - Prob. 17.4.4AYLOCh. 17 - Prob. 17.4.5AYLOCh. 17 - Prob. 17.4.6AYLOCh. 17 - Prob. 17.4.7AYLOCh. 17 - Prob. 17.4.8AYLOCh. 17 - Prob. 17.4.9AYLOCh. 17 - The projection pathways taken by retinal signals...Ch. 17 - Prob. 17.4.11AYLOCh. 17 - Prob. 17.5.1AYLOCh. 17 - Prob. 17.5.2AYLOCh. 17 - Prob. 17.5.3AYLOCh. 17 - How the lens, vitreous body, anterior chamber,...Ch. 17 - Hot and cold stimuli are detected by free nerve...Ch. 17 - Prob. 2TYRCh. 17 - Prob. 3TYRCh. 17 - Prob. 4TYRCh. 17 - The sensory neurons that begin in the spiral organ...Ch. 17 - The spiral organ rests on the tympanic membrane....Ch. 17 - Prob. 7TYRCh. 17 - Prob. 8TYRCh. 17 - Prob. 9TYRCh. 17 - Prob. 10TYRCh. 17 - The most finely detailed vision occurs when an...Ch. 17 - Fibers of the optic nerve come from the...Ch. 17 - A sensory nerve ending specialized to detect...Ch. 17 - The gelatinous membranes of the macula sacculi and...Ch. 17 - Three rows of ____________ in the cochlea have...Ch. 17 - The __________ is a tiny bone that vibrates in the...Ch. 17 - The ___________ of the midbrain receive auditory...Ch. 17 - The apical microvilli of a gustatory cell are...Ch. 17 - Olfactory neurons synapse with mitral cells and...Ch. 17 - Prob. 20TYRCh. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - Prob. 8BYMVCh. 17 - State a meaning of each word element and give a...Ch. 17 - Prob. 10BYMVCh. 17 - Determine which five of the following statements...Ch. 17 - Briefly explain why each of the following...Ch. 17 - Prob. 3TOFCh. 17 - Briefly explain why each of the following...Ch. 17 - Determine which five of the following statements...Ch. 17 - Prob. 6TOFCh. 17 - Prob. 7TOFCh. 17 - Prob. 8TOFCh. 17 - Briefly explain why each of the following...Ch. 17 - Briefly explain why each of the following...Ch. 17 - Prob. 1TYCCh. 17 - What type of cutaneous receptor enables you to...Ch. 17 - Predict the consequences of a hypothetical...Ch. 17 - Prob. 4TYCCh. 17 - Prob. 5TYC
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