Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 17, Problem 18P
Interpretation Introduction

(a)

Interpretation:

The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Interpretation Introduction

(a)

Interpretation:

If patients respond to DCA, then conclude the activity of pyruvate dehydrogenase.

Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

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