(a) Interpretation: The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity. Concept Introduction: PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

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Answer 1

Question

Chapter 17, Problem 14P

Interpretation Introduction

(a)

Interpretation:

The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Interpretation Introduction

(b)

Interpretation:

The activity of PDH should be determined in the patients who are treated with DCA.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

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You’ve isolated a protein and determined that the Native molecular weight of the holoenzyme is 160 kD using size exclusion chromatography. Analysis of this protein using SDS-PAGE revealed 2 bands, one at 100 kD and one at 30 kD. The enzyme was found to be 0.829% NAD (by weight). What further can be said regarding the structure of the polypeptide?

Answer 2

Question

Chapter 17, Problem 14P

Interpretation Introduction

(a)

Interpretation:

The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Interpretation Introduction

(b)

Interpretation:

The activity of PDH should be determined in the patients who are treated with DCA.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

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Answer 3

Question

Chapter 17, Problem 14P

Interpretation Introduction

(a)

Interpretation:

The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Interpretation Introduction

(b)

Interpretation:

The activity of PDH should be determined in the patients who are treated with DCA.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

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Answer 4

Question

Chapter 17, Problem 14P

Interpretation Introduction

(a)

Interpretation:

The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Interpretation Introduction

(b)

Interpretation:

The activity of PDH should be determined in the patients who are treated with DCA.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

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Answer 5

Chapter 17, Problem 14P

Interpretation Introduction

(a)

Interpretation:

The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Interpretation Introduction

(b)

Interpretation:

The activity of PDH should be determined in the patients who are treated with DCA.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Answer 6

Chapter 17, Problem 14P

Interpretation Introduction

(a)

Interpretation:

The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Answer 7

Chapter 17, Problem 14P

Interpretation Introduction

(a)

Interpretation:

The mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The activity of PDH should be determined in the patients who are treated with DCA.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The activity of PDH should be determined in the patients who are treated with DCA.

Concept Introduction:

PDH deficiency (pyruvate dehydrogenase deficiency) is a very common neurodegenerative disorder. It is also associated with abnormal mitochondrial metabolism and is an X-linked disorder. Pyruvate dehydrogenase complex is a very important enzyme, as it is required in the conversion of lactic acid into pyruvate, and vice-versa.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 17 - Prob. 1P Ch. 17 - Prob. 2P Ch. 17 - Prob. 3P Ch. 17 - Prob. 4P Ch. 17 - Prob. 5P Ch. 17 - Prob. 6P Ch. 17 - Prob. 7P Ch. 17 - Prob. 8P Ch. 17 - Prob. 9P Ch. 17 - Prob. 10P

Solution Summary: The author explains the mechanism of action of DCA in stimulating pyruvate dehydrogenase activity.

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