(a) Interpretation: The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity. Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

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Answer 1

Question

Chapter 17, Problem 13P

Interpretation Introduction

(a)

Interpretation:

The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Interpretation Introduction

(a)

Interpretation:

If patients respond to DCA, then conclude the activity of pyruvate dehydrogenase.

Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

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You’ve isolated a protein and determined that the Native molecular weight of the holoenzyme is 160 kD using size exclusion chromatography. Analysis of this protein using SDS-PAGE revealed 2 bands, one at 100 kD and one at 30 kD. The enzyme was found to be 0.829% NAD (by weight). What further can be said regarding the structure of the polypeptide?

Answer 2

Question

Chapter 17, Problem 13P

Interpretation Introduction

(a)

Interpretation:

The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Interpretation Introduction

(a)

Interpretation:

If patients respond to DCA, then conclude the activity of pyruvate dehydrogenase.

Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Expert Solution & Answer

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Answer 3

Question

Chapter 17, Problem 13P

Interpretation Introduction

(a)

Interpretation:

The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Interpretation Introduction

(a)

Interpretation:

If patients respond to DCA, then conclude the activity of pyruvate dehydrogenase.

Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Expert Solution & Answer

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See solution

Answer 4

Question

Chapter 17, Problem 13P

Interpretation Introduction

(a)

Interpretation:

The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Interpretation Introduction

(a)

Interpretation:

If patients respond to DCA, then conclude the activity of pyruvate dehydrogenase.

Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Expert Solution & Answer

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See solution

Answer 5

Chapter 17, Problem 13P

Interpretation Introduction

(a)

Interpretation:

The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Interpretation Introduction

(a)

Interpretation:

If patients respond to DCA, then conclude the activity of pyruvate dehydrogenase.

Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Answer 6

Chapter 17, Problem 13P

Interpretation Introduction

(a)

Interpretation:

The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Answer 7

Chapter 17, Problem 13P

Interpretation Introduction

(a)

Interpretation:

The way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

Concept introduction:

Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It helps in the conversion of pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Answer 8

Interpretation Introduction

(a)

Interpretation:

If patients respond to DCA, then conclude the activity of pyruvate dehydrogenase.

Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Answer 9

Interpretation Introduction

(a)

Interpretation:

If patients respond to DCA, then conclude the activity of pyruvate dehydrogenase.

Concept introduction: Pyruvate dehydrogenase enzyme complex is required for the linking of glycolysis and TCA. It converts the pyruvate into Acetyl CoA. Acetyl CoA then enters into the series of the citric acid cycle.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 17 - Prob. 1P Ch. 17 - Prob. 2P Ch. 17 - Prob. 3P Ch. 17 - Prob. 4P Ch. 17 - Prob. 5P Ch. 17 - Prob. 6P Ch. 17 - Prob. 7P Ch. 17 - Prob. 8P Ch. 17 - Prob. 9P Ch. 17 - Prob. 10P

Solution Summary: The author explains the way in which dichloroacetate or DCA stimulates the pyruvate dehydrogenase activity.

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