EBK HUMAN ANATOMY
9th Edition
ISBN: 9780135241752
Author: Marieb
Publisher: PEARSON CO
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Chapter 16, Problem 6CRCAQ
Summary Introduction
To review:
The cause of constant non-stop buzzing sound, name of the condition, and the treatment options that she might receive.
Introduction:
The receptors present in the ears receive various sound waves for hearing from the external environment. Various conditions might lead to hearing loss and some of these causes include exposure to loud noise for a prolonged duration, medications that might damage the nerves present in the ear, and infections associated with the middle ear.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 16 Solutions
EBK HUMAN ANATOMY
Ch. 16 - Prob. 1CYUCh. 16 - What type of cell are the olfactory receptors?...Ch. 16 - Prob. 3CYUCh. 16 - What muscle is not functioning in a person whose...Ch. 16 - Prob. 5CYUCh. 16 - Prob. 6CYUCh. 16 - Prob. 7CYUCh. 16 - Prob. 8CYUCh. 16 - Prob. 9CYUCh. 16 - Prob. 10CYU
Ch. 16 - Prob. 11CYUCh. 16 - Prob. 12CYUCh. 16 - Prob. 13CYUCh. 16 - Which auditory ossicle abuts the tympanic...Ch. 16 - Prob. 15CYUCh. 16 - Prob. 16CYUCh. 16 - Prob. 17CYUCh. 16 - Prob. 18CYUCh. 16 - What type of deafness results from damage to the...Ch. 16 - Prob. 20CYUCh. 16 - What brain regions receive input from the...Ch. 16 - Prob. 1RQCh. 16 - Prob. 2RQCh. 16 - The transmission of sound vibrations through the...Ch. 16 - Of the neurons in the retina, which form the optic...Ch. 16 - Blocking the scleral venous sinus might result in...Ch. 16 - Conduction of sound from the middle ear to the...Ch. 16 - The structure that allows the air pressure in the...Ch. 16 - The receptors for static equilibrium that report...Ch. 16 - Paralysis of a medial rectus muscle would affect...Ch. 16 - Prob. 10RQCh. 16 - The optic disc is the site where (a) more rods...Ch. 16 - Prob. 12RQCh. 16 - Prob. 13RQCh. 16 - (a) What is the precise location of the olfactory...Ch. 16 - Prob. 15RQCh. 16 - Name two special senses whose receptor cells are...Ch. 16 - (a) Describe the embryonic derivation of the...Ch. 16 - Prob. 18RQCh. 16 - Prob. 19RQCh. 16 - Compare and contrast the functions of the interior...Ch. 16 - (a) What is the difference, if any, between a...Ch. 16 - Prob. 22RQCh. 16 - Prob. 1CRCAQCh. 16 - Prob. 2CRCAQCh. 16 - Dr. Nakvarati used an instrument to blow a puff of...Ch. 16 - Lionel suffered a ruptured artery in his middle...Ch. 16 - Prob. 5CRCAQCh. 16 - Prob. 6CRCAQCh. 16 - Prob. 7CRCAQ
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