Chapter 16, Problem 2E

Summary Introduction

To explain: The physiological advantage in the mechanism where the binding of glucose to glycogen phosphorylase competitively inhibits the enzyme.

Concept introduction:

Phosphorylase is an enzyme that adds a phosphate group to the substrate from an inorganic phosphate. Glycogen phosphorylase reaction partially depends on the concentrations of substrate and product. The enzyme glycogen phosphorylase removes glucose from the glycogen polymer chain and phosphorylates to generate glucose-1-phosphate (G1P). Then, G1P quickly isomerizes to glucose-6-phosphate (G6P) by phosphoglucomutase and enters into glycolysis.