The following: (a) Neutral Polymorphism. (b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer. (c) PM2 polymorphism results in a neutral missense mutation or a silent mutation. (d) PM3 polymorphism results in a neutral missense mutation or a silent mutation. Introduction: Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single nucleotide polymorphisms (SNPs), tandem repeat polymorphisms, structural polymorphisms (like deletions and inversions), and sequence polymorphisms. The table below shows the neutral polymorphisms in BRCA 1 gene: Neutral Polymorphisms in BRCA1 Name Codon Location Base in codon+ Frequency in Control Chromosomes ∗ A G T C PM3 1619 1 116 52 0 0 PM7 1190 2 109 53 0 0 PM1 317 2 152 10 0 0 PM6 878 2 0 0 100 55 PM2 1443 3 0 0 58 115 ∗ The number of chromosomes having the particular base at the indicated polymorphic site (A, G, T or C) is shown. + Position (1, 2, or 3) of the codon.

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Question

Chapter 16, Problem 28PDQ

Summary Introduction

To review:

The following:

(a) Neutral Polymorphism.

(b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer.

(c) PM2 polymorphism results in a neutral missense mutation or a silent mutation.

(d) PM3 polymorphism results in a neutral missense mutation or a silent mutation.

Introduction:

Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single nucleotide polymorphisms (SNPs), tandem repeat polymorphisms, structural polymorphisms (like deletions and inversions), and sequence polymorphisms. The table below shows the neutral polymorphisms in BRCA 1 gene:

Neutral Polymorphisms in BRCA1

Name Codon Location Base in codon+ Frequency in Control Chromosomes ∗

A G T C

PM3 1619 1 116 52 0 0

PM7 1190 2 109 53 0 0

PM1 317 2 152 10 0 0

PM6 878 2 0 0 100 55

PM2 1443 3 0 0 58 115

∗ The number of chromosomes having the particular base at the indicated polymorphic site (A, G, T or C) is shown. + Position (1, 2, or 3) of the codon.

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Answer 2

Question

Chapter 16, Problem 28PDQ

Summary Introduction

To review:

The following:

(a) Neutral Polymorphism.

(b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer.

(c) PM2 polymorphism results in a neutral missense mutation or a silent mutation.

(d) PM3 polymorphism results in a neutral missense mutation or a silent mutation.

Introduction:

Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single nucleotide polymorphisms (SNPs), tandem repeat polymorphisms, structural polymorphisms (like deletions and inversions), and sequence polymorphisms. The table below shows the neutral polymorphisms in BRCA 1 gene:

Neutral Polymorphisms in BRCA1

Name Codon Location Base in codon+ Frequency in Control Chromosomes ∗

A G T C

PM3 1619 1 116 52 0 0

PM7 1190 2 109 53 0 0

PM1 317 2 152 10 0 0

PM6 878 2 0 0 100 55

PM2 1443 3 0 0 58 115

∗ The number of chromosomes having the particular base at the indicated polymorphic site (A, G, T or C) is shown. + Position (1, 2, or 3) of the codon.

Expert Solution & Answer

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Answer 3

Question

Chapter 16, Problem 28PDQ

Summary Introduction

To review:

The following:

(a) Neutral Polymorphism.

(b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer.

(c) PM2 polymorphism results in a neutral missense mutation or a silent mutation.

(d) PM3 polymorphism results in a neutral missense mutation or a silent mutation.

Introduction:

Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single nucleotide polymorphisms (SNPs), tandem repeat polymorphisms, structural polymorphisms (like deletions and inversions), and sequence polymorphisms. The table below shows the neutral polymorphisms in BRCA 1 gene:

Neutral Polymorphisms in BRCA1

Name Codon Location Base in codon+ Frequency in Control Chromosomes ∗

A G T C

PM3 1619 1 116 52 0 0

PM7 1190 2 109 53 0 0

PM1 317 2 152 10 0 0

PM6 878 2 0 0 100 55

PM2 1443 3 0 0 58 115

∗ The number of chromosomes having the particular base at the indicated polymorphic site (A, G, T or C) is shown. + Position (1, 2, or 3) of the codon.

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Answer 4

Question

Chapter 16, Problem 28PDQ

Summary Introduction

To review:

The following:

(a) Neutral Polymorphism.

(b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer.

(c) PM2 polymorphism results in a neutral missense mutation or a silent mutation.

(d) PM3 polymorphism results in a neutral missense mutation or a silent mutation.

Introduction:

Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single nucleotide polymorphisms (SNPs), tandem repeat polymorphisms, structural polymorphisms (like deletions and inversions), and sequence polymorphisms. The table below shows the neutral polymorphisms in BRCA 1 gene:

Neutral Polymorphisms in BRCA1

Name Codon Location Base in codon+ Frequency in Control Chromosomes ∗

A G T C

PM3 1619 1 116 52 0 0

PM7 1190 2 109 53 0 0

PM1 317 2 152 10 0 0

PM6 878 2 0 0 100 55

PM2 1443 3 0 0 58 115

∗ The number of chromosomes having the particular base at the indicated polymorphic site (A, G, T or C) is shown. + Position (1, 2, or 3) of the codon.

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Answer 5

Chapter 16, Problem 28PDQ

Summary Introduction

To review:

The following:

(a) Neutral Polymorphism.

(b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer.

(c) PM2 polymorphism results in a neutral missense mutation or a silent mutation.

(d) PM3 polymorphism results in a neutral missense mutation or a silent mutation.

Introduction:

Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single nucleotide polymorphisms (SNPs), tandem repeat polymorphisms, structural polymorphisms (like deletions and inversions), and sequence polymorphisms. The table below shows the neutral polymorphisms in BRCA 1 gene:

Neutral Polymorphisms in BRCA1

Name Codon Location Base in codon+ Frequency in Control Chromosomes ∗

A G T C

PM3 1619 1 116 52 0 0

PM7 1190 2 109 53 0 0

PM1 317 2 152 10 0 0

PM6 878 2 0 0 100 55

PM2 1443 3 0 0 58 115

∗ The number of chromosomes having the particular base at the indicated polymorphic site (A, G, T or C) is shown. + Position (1, 2, or 3) of the codon.

Answer 6

Chapter 16, Problem 28PDQ

Summary Introduction

To review:

The following:

(a) Neutral Polymorphism.

(b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer.

(c) PM2 polymorphism results in a neutral missense mutation or a silent mutation.

(d) PM3 polymorphism results in a neutral missense mutation or a silent mutation.

Introduction:

Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single nucleotide polymorphisms (SNPs), tandem repeat polymorphisms, structural polymorphisms (like deletions and inversions), and sequence polymorphisms. The table below shows the neutral polymorphisms in BRCA 1 gene:

Neutral Polymorphisms in BRCA1

Name Codon Location Base in codon+ Frequency in Control Chromosomes ∗

A G T C

PM3 1619 1 116 52 0 0

PM7 1190 2 109 53 0 0

PM1 317 2 152 10 0 0

PM6 878 2 0 0 100 55

PM2 1443 3 0 0 58 115

∗ The number of chromosomes having the particular base at the indicated polymorphic site (A, G, T or C) is shown. + Position (1, 2, or 3) of the codon.

Answer 7

Chapter 16, Problem 28PDQ

Summary Introduction

To review:

The following:

(a) Neutral Polymorphism.

(b) The significance of the table in the context of examining a family or population for BRCA1 that predispose an individual to cancer.

(c) PM2 polymorphism results in a neutral missense mutation or a silent mutation.

(d) PM3 polymorphism results in a neutral missense mutation or a silent mutation.

Introduction:

Polymorphism occurs when locus of a gene is occupied by two or more alleles within a population. Types of polymorphisms are protein/enzyme polymorphisms and DNA (deoxyribonucleic acid) polymorphisms. DNA polymorphism is further segregated into neutral polymorphisms like Single nucleotide polymorphisms (SNPs), tandem repeat polymorphisms, structural polymorphisms (like deletions and inversions), and sequence polymorphisms. The table below shows the neutral polymorphisms in BRCA 1 gene:

Neutral Polymorphisms in BRCA1

Name Codon Location Base in codon+ Frequency in Control Chromosomes ∗

A G T C

PM3 1619 1 116 52 0 0

PM7 1190 2 109 53 0 0

PM1 317 2 152 10 0 0

PM6 878 2 0 0 100 55

PM2 1443 3 0 0 58 115

∗ The number of chromosomes having the particular base at the indicated polymorphic site (A, G, T or C) is shown. + Position (1, 2, or 3) of the codon.

Answer 8

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Ch. 16 - CASE STUDY | I thought it was safe A middle-aged...Ch. 16 - CASE STUDY | I thought it was safe A middle-aged...Ch. 16 - CASE STUDY | I thought it was safe A middle-aged...Ch. 16 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 16 - 2. Review the Chapter Concepts list on page 307....Ch. 16 - What is the relationship between signal...Ch. 16 - Where are the major regulatory points in the cell...Ch. 16 - 5. Describe kinases and cyclins. How do they...Ch. 16 - (a) How does pRB function to keep cells at the G1...Ch. 16 - What is the difference between saying that cancer...

Solution Summary: The author explains the significance of the table in the con of examining a family or population for BRCA1.

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Chapter 16 Solutions

Name	Codon Location	Base in codon+	Frequency in Control Chromosomes ∗
Name	Codon Location	Base in codon+				A	G	T	C
PM3	1619	1	116	52	0	0
PM7	1190	2	109	53	0	0
PM1	317	2	152	10	0	0
PM6	878	2	0	0	100	55
PM2	1443	3	0	0	58	115