The chances of occurrence of cancer if both copies of the Rb gene and both the copies of the E2F gene become inactive due to mutations. Introduction: The malfunctioning in the process of cell differentiation causes the accumulation of cells at a specific place of the body. The accumulation of cells results in the condition of cancer. There are various mutagens present in the environmental conditions that influence the working pathway of the process of the cell cycle.

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Chapter 15.4, Problem 4CC

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To describe: The chances of occurrence of cancer if both copies of the Rb gene and both the copies of the E2F gene become inactive due to mutations.

Introduction: The malfunctioning in the process of cell differentiation causes the accumulation of cells at a specific place of the body. The accumulation of cells results in the condition of cancer. There are various mutagens present in the environmental conditions that influence the working pathway of the process of the cell cycle.

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FBBS 2 Worksheet 2 Name HINT: when you are explaining mechanisms affected by mutations, think about molecular interactions, or enzymatic functions, or conformational changes that are involved in the normal pathways, since these are the aspects most likely to be affected by mutations or drugs, or viral proteins. If a consequence of a mutation/drug/virus results in a cdk being more frequently active, then the cell cycle will proceed at the given checkpoint. If the consequence of a mutation/drug/virus results in a cdk being inactivated or inhibited, then the cell cycle is stopped at the given checkpoint. cdc2 kinase Inactive 1) Given the following diagram of a mechanism regulating the cell cycle of the fission yeast S. pombe. Interphase (G₂) CAK Wee1 Cyclin Thr161-P Tyr15-P cdc2 kinase Cyclin Inactive Thr161-P cdc25 G₂ fission yeast cell cdc2 kinase Cyclin Active Interphase (G₁) Post-mitotic fission yeast cells Date cdc2 kinase Dr. Milani Inactive Cyclin Degradation A) Predict the…

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