Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 15.4, Problem 1R
Summary Introduction
To review:
The comparison of advantages between genotypic screening by allele-specific oligonucleotide hybridization and
Introduction:
Genetic screening is a process, used to detect genetic disease of a person who is either carrier or susceptible to the disease. There are two types of genetic screening that are done to identify a genetic disease. These are genotypic and phenotypic screening.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
A complex biochemical pathway is shown below, along with the alleles that either promote or
inhibit each step of the pathway leading to a phenotype. Gene A has alleles A and a, B has alleles
B and b, and so forth. Genes B and C are duplicate dominant epistatic lethal as heterozygotes
(i.e. Bb Cc are lethal). Genes D and E are duplicate dominant epistatic (i.e. dd eg = desired
phenotype). If I were to cross AA Bb cc Dd Ee with aa BB Cc Dd e,
(i)
(ii) What proportion of all offspring don't show the phenotype?
What proportion of offspring survive?
Gene A
Gene B
B Gene D
a
Gene C
Gene E
Why are maternal effect genes so difficult to identify via mutant analysis?
Explain at the biochemical or enzymatic level, the phenotypic consequencesof alleles incase of following cross.
Rr (pink flower) x Rr (pink flower) (progeny are 1 RR (red flower) :2 Rr (pink flower): 1rr(white flower)
how alleles contribute to a phenotype through metabolism.
Chapter 15 Solutions
Life: The Science of Biology
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which of the following best explains how individuals who inherit phenylketonuria alleles can avoid the symptoms of this disease (mental impairment, foul smelling urine)? It exhibits variable expressivity. The expression of this disease depends on the environment. If the individual removes phenylalanine from their diet they can avoid the disease entirely. PKU alleles are epistatic to alleles of another gene, which acts downstream in phenylalanine metabolism. These individuals supplement their diets with enzymes that break-down phenylalanine.arrow_forwardWhat is meant by Genetic Information NondiscriminationAct (GINA) ?arrow_forwardWhat is dosage compensation? Give its importance. explain pleasearrow_forward
- Talk about the challenges involved in determining the genetic components of polygenic illnesses. Explain complementation groups and how the biochemical underpinnings of disease are determined using them. Hereditary illnesses of genomic instability include Werner syndrome, Bloom syndrome, XP, ataxia-telangiectasia, and Fanconi anemia. Which of these ailments has molecular mechanisms behind it? Which kind of genetic instability is connected to which disorder?.arrow_forwardWhat is a molecular marker? Give two examples. Discuss why it isgenerally easier to locate and map molecular markers rather thanfunctional genes.arrow_forwardMultiple crosses were made between true-breeding lines of black and yellow Labrador retrievers. All the F1 progeny were yellow. When these progeny were intercrossed, they produced an F2 consisting of 121 yellow, 9 black and 30 chocolate. What epistatic ratio and what kind of epistasis is approximated in the F2? Propose a biochemical pathway for coat color in Labrador retrievers based on the type of epistasis. Correlate each genotype with the phenotype that would occur in your pathway. Also show the frequency of each genotype. A-B- A-bb aaB- aabbarrow_forward
- In your attempts to identify a genetic basis for rheumatoid arthritis in humans, you have DNA samples from three large unrelated families in which individuals with varying severity of rheumatoid arthritis are found. From your analysis of various SNPs, you find that the same four unlinked loci consistently show a correlation with the most severe cases from all three families. Based on your observations, which of the following hypotheses best describes the genetic control of rheumatoid arthritis? ос Rheumatoid arthritis is the result of phenocopy by the environment Different genes regulate the disease in different families Rheumatoid arthritis is controlled by a single X-linked recessive trait Rheumatoid arthritis is controlled by polygenic (or quantitative) traits Rheumatoid arthritis is controlled by a single autosomal dominant traitarrow_forwardIn a study, an undergraduate student discovered a new enzyme involved in the metabolism of serotonin. This enzyme is made up of 3 subunits of the same protein. To characterize this enzyme, the student used genetic approaches to induce mutations in the coding region of the gene that codes for this protein and performed crosses to measure the effects of genotypes on enzyme activity. A) Indicate directly in the diagram (via a bar graph) the predicted relationship between genotype and enzyme activity. (Al represents the wild-type allele, A2 represents the mutant allele). A2A2 A1A2 A1Α1 B) Explain the reasoning for your prediction. Enzyme Activityarrow_forwardGg.193.arrow_forward
- Until very recently, the fitness of an individual getting familial retinoblastoma was zero, and if the frequency of babies with the inherited disease is 1/20000, what is the best estimate of the mutation rate of the wild type allele to the non-functional form?arrow_forward3) You have identified an interesting mutant in gene P. Using a Punnett square, demonstrate the cross you perform to determine if it is a dominant or recessive mutation compared to the WT gene P allele. Write the expected ratios for either scenario. 4) You have determined the mutation is dominant when compared to the WT allele. Briefly describe a technique you could use to determine if expression levels of gene P have been altered in this mutant. 5) You have determined the expression level of gene P has increased. What class/type of mutation would cause this?arrow_forwardProvide one example of a clinical implication of a “silent mutation” that proven to have an effect on the phenotype and provide a brief description of its molecular characteristics?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Concepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax College
Concepts of Biology
Biology
ISBN:9781938168116
Author:Samantha Fowler, Rebecca Roush, James Wise
Publisher:OpenStax College
An Introduction to the Human Genome | HMX Genetics; Author: Harvard University;https://www.youtube.com/watch?v=jEJp7B6u_dY;License: Standard Youtube License