CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
8th Edition
ISBN: 9781259880193
Author: SALADIN
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 15.1, Problem 2AYLO
Why this system is called autonomic; how it differs from the somatic motor system
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 15 Solutions
CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
Ch. 15.1 - The fundamental function and effectors of the...Ch. 15.1 - Why this system is called autonomic; how it...Ch. 15.1 - Prob. 3AYLOCh. 15.1 - Why it cannot be said that at any given moment,...Ch. 15.1 - Basic anatomical components of the ANSCh. 15.1 - How autonomic efferent pathways differ from...Ch. 15.1 - Prob. 1BYGOCh. 15.2 - Prob. 1AYLOCh. 15.2 - Anatomy of the sympathetic chain; the number of...Ch. 15.2 - Prob. 3AYLO
Ch. 15.2 - Differences between the spinal nerve route,...Ch. 15.2 - Prob. 5AYLOCh. 15.2 - Prob. 6AYLOCh. 15.2 - The degree and significance of neural divergence...Ch. 15.2 - Why the adrenal medulla can be considered part of...Ch. 15.2 - Names and numbers of the cranial and spinal nerves...Ch. 15.2 - Prob. 10AYLOCh. 15.2 - Prob. 11AYLOCh. 15.2 - The location and functions of the enteric nervous...Ch. 15.2 - Explain why the sympathetic division is also...Ch. 15.2 - Prob. 4BYGOCh. 15.3 - Prob. 1AYLOCh. 15.3 - Prob. 2AYLOCh. 15.3 - Prob. 3AYLOCh. 15.3 - Prob. 4AYLOCh. 15.3 - Prob. 5AYLOCh. 15.3 - Prob. 6AYLOCh. 15.3 - Autonomic control of certain organs by dual...Ch. 15.3 - Prob. 8AYLOCh. 15.3 - Prob. 10BYGOCh. 15.3 - Prob. 11BYGOCh. 15.4 - Examples of the influence of the cerebral cortex,...Ch. 15 - Baro -Ch. 15 - Lyto-Ch. 15 - Prob. 3BYMVCh. 15 - Prob. 4BYMVCh. 15 - Prob. 5BYMVCh. 15 - Prob. 6BYMVCh. 15 - reno-Ch. 15 - Prob. 8BYMVCh. 15 - Prob. 9BYMVCh. 15 - Prob. 10BYMVCh. 15 - Prob. 1TYRCh. 15 - Muscarinic receptors bind a. epinephrine. b....Ch. 15 - All of the following cranial nerves except the...Ch. 15 - Which of the following cranial nerves carries...Ch. 15 - Prob. 5TYRCh. 15 - Epinephrine is secreted by a. sympathetic...Ch. 15 - Prob. 7TYRCh. 15 - The gray communicating ramus contains a. visceral...Ch. 15 - Prob. 9TYRCh. 15 - Which of these does not result from sympathetic...Ch. 15 - Certain nerve fibers are called _______ fibers...Ch. 15 - Prob. 12TYRCh. 15 - Prob. 13TYRCh. 15 - Most parasympathetic preganglionic fibers arc...Ch. 15 - Prob. 15TYRCh. 15 - Prob. 16TYRCh. 15 - Prob. 17TYRCh. 15 - Prob. 18TYRCh. 15 - Prob. 19TYRCh. 15 - Prob. 20TYRCh. 15 - Prob. 1WWTSCh. 15 - The parasympathetic nervous system controls...Ch. 15 - Voluntary control of the ANS is not possible.Ch. 15 - Prob. 4WWTSCh. 15 - Prob. 5WWTSCh. 15 - Prob. 6WWTSCh. 15 - Prob. 7WWTSCh. 15 - Prob. 8WWTSCh. 15 - Prob. 9WWTSCh. 15 - The two divisions of the ANS have cooperative...Ch. 15 - You are dicing raw onions while preparing dinner,...Ch. 15 - Prob. 2TYCCh. 15 - Prob. 3TYCCh. 15 - What would be the advantage to a wolf in having...Ch. 15 - Pediatric literature has reported many cases of...Ch. 15 - Prob. 1BYGOCh. 15 - Prob. 2BYGOCh. 15 - Prob. 3BYGOCh. 15 - Prob. 4BYGOCh. 15 - Prob. 5BYGOCh. 15 - Prob. 6BYGOCh. 15 - Prob. 7BYGOCh. 15 - Prob. 8BYGOCh. 15 - Prob. 9BYGOCh. 15 - Prob. 10BYGOCh. 15 - Prob. 11BYGOCh. 15 - Prob. 12BYGOCh. 15 - Prob. 13BYGOCh. 15 - Prob. 14BYGOCh. 15 - Prob. 15BYGO
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