The classical morphogen signals other than Shh, which are responsible for attracting commissural axons to the floor plate. Whether dorsoventral pathfinding is affected by BMPs of the dorsal neural tube or can Wnts influence the longitudinal axon guidance. Introduction: Santiago Ramony Cajal (1892) first proposed that axons are guided by the chemotactic molecules in the developing nervous system. He suggested that signaling to the commisural neurons of the spinal cord to send the axons from dorsal position to the ventral floor plate is goverened by some diffusible molecules. One of the important morphogen is Shh (Sonic hedgehog), which initiate the process of ventral migration of commissural neurons. The concentration gradient of Shh is important for this ventral migration. But the loss of this gradient by some inhibitor likes cyclopamine does not stop the migration completely, which suggest that few other factors may involve in this migration.

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Chapter 15, Problem 6DQ

Summary Introduction

To review:

The classical morphogen signals other than Shh, which are responsible for attracting commissural axons to the floor plate. Whether dorsoventral pathfinding is affected by BMPs of the dorsal neural tube or can Wnts influence the longitudinal axon guidance.

Introduction:

Santiago Ramony Cajal (1892) first proposed that axons are guided by the chemotactic molecules in the developing nervous system. He suggested that signaling to the commisural neurons of the spinal cord to send the axons from dorsal position to the ventral floor plate is goverened by some diffusible molecules. One of the important morphogen is Shh (Sonic hedgehog), which initiate the process of ventral migration of commissural neurons. The concentration gradient of Shh is important for this ventral migration. But the loss of this gradient by some inhibitor likes cyclopamine does not stop the migration completely, which suggest that few other factors may involve in this migration.

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Question

Chapter 15, Problem 6DQ

Summary Introduction

To review:

The classical morphogen signals other than Shh, which are responsible for attracting commissural axons to the floor plate. Whether dorsoventral pathfinding is affected by BMPs of the dorsal neural tube or can Wnts influence the longitudinal axon guidance.

Introduction:

Santiago Ramony Cajal (1892) first proposed that axons are guided by the chemotactic molecules in the developing nervous system. He suggested that signaling to the commisural neurons of the spinal cord to send the axons from dorsal position to the ventral floor plate is goverened by some diffusible molecules. One of the important morphogen is Shh (Sonic hedgehog), which initiate the process of ventral migration of commissural neurons. The concentration gradient of Shh is important for this ventral migration. But the loss of this gradient by some inhibitor likes cyclopamine does not stop the migration completely, which suggest that few other factors may involve in this migration.

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Answer 3

Question

Chapter 15, Problem 6DQ

Summary Introduction

To review:

The classical morphogen signals other than Shh, which are responsible for attracting commissural axons to the floor plate. Whether dorsoventral pathfinding is affected by BMPs of the dorsal neural tube or can Wnts influence the longitudinal axon guidance.

Introduction:

Santiago Ramony Cajal (1892) first proposed that axons are guided by the chemotactic molecules in the developing nervous system. He suggested that signaling to the commisural neurons of the spinal cord to send the axons from dorsal position to the ventral floor plate is goverened by some diffusible molecules. One of the important morphogen is Shh (Sonic hedgehog), which initiate the process of ventral migration of commissural neurons. The concentration gradient of Shh is important for this ventral migration. But the loss of this gradient by some inhibitor likes cyclopamine does not stop the migration completely, which suggest that few other factors may involve in this migration.

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Answer 4

Question

Chapter 15, Problem 6DQ

Summary Introduction

To review:

The classical morphogen signals other than Shh, which are responsible for attracting commissural axons to the floor plate. Whether dorsoventral pathfinding is affected by BMPs of the dorsal neural tube or can Wnts influence the longitudinal axon guidance.

Introduction:

Santiago Ramony Cajal (1892) first proposed that axons are guided by the chemotactic molecules in the developing nervous system. He suggested that signaling to the commisural neurons of the spinal cord to send the axons from dorsal position to the ventral floor plate is goverened by some diffusible molecules. One of the important morphogen is Shh (Sonic hedgehog), which initiate the process of ventral migration of commissural neurons. The concentration gradient of Shh is important for this ventral migration. But the loss of this gradient by some inhibitor likes cyclopamine does not stop the migration completely, which suggest that few other factors may involve in this migration.

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Answer 5

Chapter 15, Problem 6DQ

Summary Introduction

To review:

The classical morphogen signals other than Shh, which are responsible for attracting commissural axons to the floor plate. Whether dorsoventral pathfinding is affected by BMPs of the dorsal neural tube or can Wnts influence the longitudinal axon guidance.

Introduction:

Santiago Ramony Cajal (1892) first proposed that axons are guided by the chemotactic molecules in the developing nervous system. He suggested that signaling to the commisural neurons of the spinal cord to send the axons from dorsal position to the ventral floor plate is goverened by some diffusible molecules. One of the important morphogen is Shh (Sonic hedgehog), which initiate the process of ventral migration of commissural neurons. The concentration gradient of Shh is important for this ventral migration. But the loss of this gradient by some inhibitor likes cyclopamine does not stop the migration completely, which suggest that few other factors may involve in this migration.

Answer 6

Chapter 15, Problem 6DQ

Summary Introduction

To review:

The classical morphogen signals other than Shh, which are responsible for attracting commissural axons to the floor plate. Whether dorsoventral pathfinding is affected by BMPs of the dorsal neural tube or can Wnts influence the longitudinal axon guidance.

Introduction:

Santiago Ramony Cajal (1892) first proposed that axons are guided by the chemotactic molecules in the developing nervous system. He suggested that signaling to the commisural neurons of the spinal cord to send the axons from dorsal position to the ventral floor plate is goverened by some diffusible molecules. One of the important morphogen is Shh (Sonic hedgehog), which initiate the process of ventral migration of commissural neurons. The concentration gradient of Shh is important for this ventral migration. But the loss of this gradient by some inhibitor likes cyclopamine does not stop the migration completely, which suggest that few other factors may involve in this migration.

Answer 7

Chapter 15, Problem 6DQ

Summary Introduction

To review:

The classical morphogen signals other than Shh, which are responsible for attracting commissural axons to the floor plate. Whether dorsoventral pathfinding is affected by BMPs of the dorsal neural tube or can Wnts influence the longitudinal axon guidance.

Introduction:

Santiago Ramony Cajal (1892) first proposed that axons are guided by the chemotactic molecules in the developing nervous system. He suggested that signaling to the commisural neurons of the spinal cord to send the axons from dorsal position to the ventral floor plate is goverened by some diffusible molecules. One of the important morphogen is Shh (Sonic hedgehog), which initiate the process of ventral migration of commissural neurons. The concentration gradient of Shh is important for this ventral migration. But the loss of this gradient by some inhibitor likes cyclopamine does not stop the migration completely, which suggest that few other factors may involve in this migration.

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Ch. 15 - Prob. 1DQ Ch. 15 - Prob. 2DQ Ch. 15 - Prob. 3DQ Ch. 15 - Prob. 4DQ Ch. 15 - Prob. 5DQ Ch. 15 - Prob. 6DQ Ch. 15 - Prob. 7DQ Ch. 15 - Prob. 8DQ Ch. 15 - Prob. 9DQ

Solution Summary: The author explains that the classical morphogen signals other than Shh are responsible for attracting commissural axons to the floor plate.

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