Developmental Biology
Developmental Biology
11th Edition
ISBN: 9781605354705
Author: Scott F. Gilbert, Michael J. F. Barresi
Publisher: Sinauer Associates is an imprint of Oxford University Press
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Chapter 15, Problem 5DQ
Summary Introduction

To review:

The role of CLASP and other families of +TIPs in localization of mRNA to the growing end of microtubules. Also explain other events in developmental biology which participate in spatially restricted pockets of mRNA and translation machinery.

Introduction:

The growth cone is an actin supported extension of developing neuron. It has two major compartment, one is the central domain which contains microtubules and second is peripheral domain which consists two types of actin-associated membrane protrusions: lamellipodia and membranous sheet. The force driving axon movement and directionality, depends upon microtubule and actin based membrane protrusion.

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