MOLECULAR BIOLOGY OF THE CELL (LL)
MOLECULAR BIOLOGY OF THE CELL (LL)
6th Edition
ISBN: 9780393876109
Author: ALBERTS
Publisher: NORTON
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Chapter 15, Problem 4P
Summary Introduction

To examine:  Whether the statement “binding of extracellular ligands to receptor tyrosine kinases (RTKs) activates the intracellular catalytic domain by propagating a conformational change across the lipid bilayer through a single transmembrane α helix” is true or false.

Introduction:

Receptor tyrosine kinases (RTKs) are transmembrane receptors in signal transduction pathways. They bind to the ligands such as growth factors and play essential roles in regulation of cellular processes. All RTKs consists of an extracellular domain with a ligand-binding site, a single transmembrane α helix, and a cytosolic domain.

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