How phosphorylation/ dephosphorylation as opposed to allosteric binding of small molecules has evolved to play a prominent role in switching proteins on and off in signaling pathways. Introduction: In cell signaling pathways, the signaling proteins act as molecular switches. Their conformation is related to their activity and regulatory mechanisms. The modulation of protein structure contributes in their switch from one conformation to other for binding to target and induce functional change. Signaling proteins are modulated by allosteric regulation or by phopshorylation.

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Chapter 15, Problem 11P

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To determine: How phosphorylation/ dephosphorylation as opposed to allosteric binding of small molecules has evolved to play a prominent role in switching proteins on and off in signaling pathways.

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In cell signaling pathways, the signaling proteins act as molecular switches. Their conformation is related to their activity and regulatory mechanisms. The modulation of protein structure contributes in their switch from one conformation to other for binding to target and induce functional change. Signaling proteins are modulated by allosteric regulation or by phopshorylation.

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